Prognostic Significance of EEG Sleep Changes in Late-Life Depression

  • C. F. ReynoldsIII
  • C. C. Hoch
  • D. J. Buysse
  • P. R. Houck
  • S. R. Berman
  • D. J. Kupfer
Conference paper


Our studies of EEG sleep changes in late-life depression have shown that these alterations have both diagnostic and prognostic significance, particularly for understanding patients with mixed clinical presentations of both depression and cognitive impairment. More recently, our work has also suggested that certain sleep changes may be associated with higher risk for recurrence of depression in late life, as well as with higher risk of mortality within 2 years. In this report, we discuss data from several ongoing and interrelated studies of sleep, aging, and depression.


NREM Sleep Total Sleep Deprivation Depressive Pseudodementia Systemic Medical Illness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders (DSM-III). American Psychiatric Association, WashingtonGoogle Scholar
  2. 2.
    Blessed G, Tomlinson BE, Roth M (1968) The association between quantitative measures of dementia and of senile change in the cerebral gray matter of elderly subjects. Br J Psychiatry 144: 797–811CrossRefGoogle Scholar
  3. 3.
    Buysse DJ, Reynolds CF, Kupfer DJ, Houck PR, Hoch CC, Stack JA, Berman SR (1988) Electroencephalographic sleep in depressive pseudodementia. Arch Gen Psychiatry 45: 568–575PubMedGoogle Scholar
  4. 4.
    Dev NB, Loefschke HH (1979) A cholinergic mechanism involved in the respiratory chemosensitivity of the medulla oblongata in the cat. Pflugers Arch 379: 29–36PubMedCrossRefGoogle Scholar
  5. 5.
    Folstein MF, Folstein SE, McHugh PR (1975) “Mini-Mental State”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198PubMedCrossRefGoogle Scholar
  6. 6.
    Giles DE, Jarrett RB, Roffwarg HP, Rush AJ (1987) Reduced rapid eye movement latency: a predictor of recurrence of depression. Neuropsychopharmacology 1: 33–39PubMedCrossRefGoogle Scholar
  7. 7.
    Hamilton M (1967) Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 6: 278–296PubMedCrossRefGoogle Scholar
  8. 8.
    Hobson JA, McCarley RW, Wyzinski PW (1975) Reciprocal discharge by two brainstem neuronal groups. Science 189: 55–58PubMedCrossRefGoogle Scholar
  9. 9.
    Hoch CC, Reynolds CF, Kupfer DJ, Houck PR, Berman SR, Stack JA (1986) Sleep-disordered breathing in normal and pathologic aging. J Clin Psychiatry 47: 499–503PubMedGoogle Scholar
  10. 10.
    Hoch CC, Reynolds CF, Houck PR, Hall F, Berman SR, Buysse DJ, Dahl R, Kupfer DJ (1989) REM latency and apnea-hypopnea index predict two-year mortality in mixed depressed-demented patients. J Neuropsychiatr Clin Neurosci 1 (4): 366–371Google Scholar
  11. 11.
    Hughes CP, Berg L, Cohen LA etal. (1982) A new clinical scale for the staging of dementia. Br J Psychiatry 140: 566–572PubMedCrossRefGoogle Scholar
  12. 12.
    Reynolds CF, Kupfer DJ, Hoch CC, Houck PR, Stack JA, Berman SR, Campbell PI, Zimmer B (1987) Sleep deprivation as a probe in the elderly. Arch Gen Psychiatry 44: 982–990PubMedGoogle Scholar
  13. 13.
    Reynolds CF, Kupfer DJ, Houck PR, Hoch CC, Stack JA, Berman SR, Zimmer B (1988) Reliable discrimination of elderly depressed and demented patients by EEG sleep data. Arch Gen Psychiatry 45: 258–264PubMedGoogle Scholar
  14. 14.
    Reynolds CF, Perel JM, Frank E, Imber S, Kupfer DJ (1989) Open-trial maintenance nortriptyline in late-life depression: survival analysis and preliminary data on the use of REM latency as a predictor of recurrence. Psychopharmacol Bull 25 (1): 129–132PubMedGoogle Scholar
  15. 15.
    Reynolds CF, Perel JM, Frank E, Imber S, Thornton JE, Morycz RK, Cornes C, Kupfer DJ (1989) Open-trial maintenance pharmacotherapy in late-life depression: survival analysis. Psychiatr Res 27: 225–231CrossRefGoogle Scholar
  16. 16.
    Spitzer RL, Endicott J, Robins E (1978) Research diagnostic criteria: rationale and reliability. Arch Gen Psychiatry 35: 773–782PubMedGoogle Scholar
  17. 17.
    US Department of Health and Human Services (1988) Health United States 1987. National Center for Health Services, Hyattsville MD, pp 56-57 (DHHS publication 88–1232 )Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • C. F. ReynoldsIII
  • C. C. Hoch
  • D. J. Buysse
  • P. R. Houck
  • S. R. Berman
  • D. J. Kupfer
    • 1
  1. 1.PittsburghUSA

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