Central Venous Oxygen Saturation, Abnormal Gas Exchange, and Rate of Fall of Arterial Oxyhemoglobin Saturation During Obstructive Apnea
The minimum (nadir) arterial oxyhemoglobin saturation (SaO2) during obstructive sleep apnea (OSA) is a function of apnea duration and rate of fall of arterial oxyhemoglobin saturation (dSaO2/dt) (Fig. 1). The longer the apnea, or the steeper the dSaO2/dt for a given duration of apnea, the lower the nadir SaO2 will be. Several factors have been shown to affect apnea duration: hypercarbia , level of oxygenation [1–4], and stage of sleep . Other studies have demonstrated that dSaO2/dt is affected by thoracic gas volume [6, 7] as well as SaO2 [8, 9] at apnea onset.
KeywordsObesity Catheter Dioxide Respiration Radionuclide
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