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Methodik und Anwendung der Nucleinsäure-Diagnostik

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Analytiker-Taschenbuch

Part of the book series: Analytiker-Taschenbuch ((ANALYTIKERTB,volume 10))

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Zusammenfassung

Die Etablierung der Technik der Nucleinsäure-Hybridisierung Mitte der sechziger Jahre durch Gillespie und Spiegelman [1] sowie Denhardt [2] machte es möglich, mit Hilfe von sequenzspezifischen Hybridisierungs- sonden bestimmte Nucleinsäure-Abschnitte neben einer Vielzahl anderer, sequenzverschiedener Abschnitte gezielt nachweisen und analysieren zu können [3, 4]. Gemeinsam mit den Ende der siebziger Jahre durch Maxam und Gilbert [5] sowie Sanger und Mitarbeiter [6] entwickelten Methoden der DNA-Sequenzierung — die in den letzten Jahren auf nicht-radioaktive Verfahren umgestellt wurden [7, 8] — bildet die Hybridisierungs- technik eines der beiden Standbeine der molekularen Nucleinsäure- Analyse.

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  1. Biochemisches Forschungszentrum Abteilung Genetik, Boehringer Mannheim GmbH, Nonnenwald 2, Penzberg, Deutschland

    C. Kessler

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    Helmut Günzler

  2. Sektion Chemie, Karl-Marx-Universität Leipzig, Talstr. 35, D-7010, Leipzig, Deutschland

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  3. Institut Fresenius, Im Maisel, D-6204, Taunusstein, Deutschland

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  6. Analytik/Qualitätskontrolle, Dr. Karl Thomae GmbH, Postfach 1755, D-7950, Biberach, Deutschland

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  7. Institut für Spektrochemie, und angewandte Spektroskopie, Bunsen-Kirchhoff-Str. 11, D-4600, Dortmund 1, Deutschland

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Kessler, C. (1991). Methodik und Anwendung der Nucleinsäure-Diagnostik. In: Günzler, H., et al. Analytiker-Taschenbuch. Analytiker-Taschenbuch, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76028-0_10

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