Genetic Epidemiology of Cancer and Predisposing Lesions
The common contribution of genetic factors to the susceptibility to common cancer is not well understood and not generally accepted. Although familial clustering of common cancers has been observed, only a minority of cases provide obvious support for an inherited component, and few family studies of random common cancers have been implemented. Only in rare syndromes such as Gardner’s syndrome, familial adenomatous polyposis, Wilm’s tumor, and retinoblastoma has the contribution of an inherited susceptibility to the etiology of cancer been confirmed.
KeywordsAdenoma Hunt Candida Kelly Weinstein
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- Anderson DE (1980) Risk in families of patients with colon cancer. In: Winawer S, Schottenfeld D, Sherlock P (eds) Colorectal cancer: prevention, epidemiology, and screening. Raven, New York, pp 109–115Google Scholar
- Cancer in Utah (1988) Statistical and epidemiological report 1973–1985. Utah Cancer Registry, Salt Lake City, UtahGoogle Scholar
- Cannon L, Bishop DT, Skolnick M, Hunt S, Lyon JL, Smart CR (1982) Genetic epidemiology of prostate cancer in the Utah Mormon genealogy. Cancer Surv 1:47–69Google Scholar
- Hill J (1980) A kinship survey of cancer in the Utah Mormon population. PhD thesis, University of UtahGoogle Scholar
- Jorde LB, Skolnick MH (1981) Demographic and genetic application of computerized record linking: the Utah Mormon genealogy. Information et Sciences Humaines 56–57:105–117Google Scholar
- Skolnick M (1980) The Utah genealogical data base: a resource for genetic epidemiology. In: Cairns J, Lyon JL, Skolnick M (eds) Banbury Report No. 4: cancer incidence in defined populations. Cold Spring Harbor Laboratory, New York, pp 285–297Google Scholar
- Skolnick M, Bean L, May D, Arbon V, de Nevers K, Cartwright P (1978) Mormon demographic history. I. Nuptiality and fertility of once-married couples. Popul Stud 32:5–19Google Scholar
- Skolnick M, Bishop DT, Carmelli D, Gardner E, Hadley R, Hasstedt, Hill JR, Hunt S, Lyon JL, Smart CR, Williams RR (1981) A population based assessment of familial cancer risk in Utah Mormon genealogies. In: Arrighi F, Rao PN, Stubblefield E (eds) Genes, Chromosomes and Neoplasia. Raven, New York, pp 477–500Google Scholar
- Weinstein B, Gattoni-Celli S, Kirschmeier P, Lambert M, Hsiao W, Backer J, Jeffrey A (1983) Multistage carcinogenesis involves multiple genes and multiple mechanisms. In: Mak TW, Tannock I (eds) Cellular and Molecular Biology of Neoplasia. Liss, New York, pp 127–138Google Scholar