Genetic Epidemiology of Cancer and Predisposing Lesions

  • L. A. Cannon-Albright
  • D. T. Bishop
  • D. E. Goldgar
  • M. H. Skolnick

Abstract

The common contribution of genetic factors to the susceptibility to common cancer is not well understood and not generally accepted. Although familial clustering of common cancers has been observed, only a minority of cases provide obvious support for an inherited component, and few family studies of random common cancers have been implemented. Only in rare syndromes such as Gardner’s syndrome, familial adenomatous polyposis, Wilm’s tumor, and retinoblastoma has the contribution of an inherited susceptibility to the etiology of cancer been confirmed.

Keywords

Adenoma Hunt Candida Kelly Weinstein 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • L. A. Cannon-Albright
    • 1
  • D. T. Bishop
    • 2
  • D. E. Goldgar
    • 3
  • M. H. Skolnick
    • 3
  1. 1.Division of Hematology/Oncology, Department of Internal MedicineUniversity of Utah School of MedicineSalt Lake CityUSA
  2. 2.Genetic Epidemiology LaboratoryImperial Cancer Research FundLeedsUK
  3. 3.Department of Medical InformaticsUniversity of Utah School of MedicineSalt Lake CityUSA

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