Familial Susceptibility to Breast Cancer

  • N. Andrieu
  • F. Clavel
  • F. Demenais
Conference paper


Familial concentrations of breast cancer, first described over 100 years ago (Broca 1866), may be due either to chance or to environmental factors common to members of the same family. They may also result from genetic susceptibility to the disease.


Breast Cancer Segregation Analysis Nuclear Family Sporadic Breast Cancer Bilateral Breast Cancer 
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  1. Andrieu N, Demenais F, Martinez M (1988) Genetic analysis of human breast cancer: implications for family study designs. Genet Epidemiol 5:225–233PubMedCrossRefGoogle Scholar
  2. Bailey-Wilson JE, Cannon LA, King MC (1986) Genetic analysis of human breast cancer: a synthesis of contributions to GAW IV. Genet Epidemiol (suppl) I: 15–35Google Scholar
  3. Bishop DT, Gardner EJ (1980) Analysis of the genetic predisposition to cancer in individual pedigrees. In: Cairns J, Lyons JL, Skolnick M (eds) Cancer incidence in defined populations. Banbury Report 4. Cold Spring Harbor, New York, pp 389Google Scholar
  4. Bishop DT, Cannon-Albright L, McLellan T, Gardner EJ, Skolnick MH (1988) Segregation and linkage analysis of nine Utah breast cancer pedigrees. Genet Epidemiol 5:151–169PubMedCrossRefGoogle Scholar
  5. Bonney GE (1986) Regression logistic models for familial disease and other binary traits. Biometrics 42:611–625PubMedCrossRefGoogle Scholar
  6. Broca P (1866) Traité des tumeurs. In: Anselin, Becket, Labe (eds) Des tumeurs en général. ParisGoogle Scholar
  7. Demenais F, Martinez M, Bonaiti-Pellie C, Clerget-Darpoux F, Feingold N (1986) Segregation analysis of the Jacobsen data. Genet Epidemiol (suppl) 1:49–54CrossRefGoogle Scholar
  8. Gilligan SB, Borecki IB (1986) Examination of heterogeneity in 200 Danish breast cancer pedigrees. Genet Epidemiol (suppl) 1:67–72CrossRefGoogle Scholar
  9. Go RCP, King MC, Bailey-Wilson J, Elston RC, Lynch HT (1983) Genetic epidemiology of breast and associated cancers in high risk families. I. Segregation analysis. J Natl Cancer Inst 71:455–561PubMedGoogle Scholar
  10. Goldstein AM, Haile RWC, Marazita ML, Paganini-Hill A (1987) A genetic epidemiologic investigation of breast cancer in families with bilateral breast cancer. I. Segregation analysis. J Natl Cancer Inst 78:911–918PubMedGoogle Scholar
  11. Goldstein AM, Haile RWC, Hodge SE, Paganini-Hill A, Spence MA (1988) Possible heterogeneity in the segregation pattern of breast cancer in families with bilateral breast cancer. Genet Epidemiol 5:121–133PubMedCrossRefGoogle Scholar
  12. Hill JR, Carmelli D, Gardner EJ, Skolnick M (1978) Likelihood analysis of breast cancer predisposition in a Mormon pedigree. In: Morton NE, Chung CS (eds) Genetic epidemiology. Academic, New York, pp 304–310Google Scholar
  13. Hopper JL, Derrick PL (1986) A log-linear model for binary pedigree data. Genet Epidemiol (suppl) 1:73–82CrossRefGoogle Scholar
  14. Jacobsen O (1946) Heredity in breast cancer. In: Lewis HK (ed) A genetic and clinical study of two hundred probands. London, pp 1–306Google Scholar
  15. Kelsey JL (1979) A review of the epidemiology of human breast cancer. Epidemiol Rev 1:74–109PubMedGoogle Scholar
  16. Knudson AG (1971) Mutation and cancer: statistical study of retinoblastomas. Proc Natl Acad Sci USA 68:820–823PubMedCrossRefGoogle Scholar
  17. Morton NE, MacLean CJ (1974) Analysis of family resemblance. III. Complex segregation of quantitative traits. Am J Hum Genet 26:489–503PubMedGoogle Scholar
  18. Newman B, Austin MA, Lee M, King MC (1988) Inheritance of human breast cancer: evidence for autosomal dominant transmission in high-risk families. Proc Natl Acad Sci USA 85:3044–3048PubMedCrossRefGoogle Scholar
  19. Petrakis NL, Ernster VL, King MC (1982) Breast cancer. In: Schottenfeld D, Fraumeni JF (eds) Cancer epidemiology and prevention. Saunders, Philadelphia, p 855Google Scholar
  20. Skolnick MH, Thomson EA, Bishop DT, Cannon LA (1984) Possible linkage of a breast cancer susceptibility locus to the ABO locus: sensitivity of LOD scores to a single new recombinant observation. Genet Epidemiol 1:363–373PubMedCrossRefGoogle Scholar
  21. Williams WR, Anderson DE (1984) Genetic epidemiology of breast cancer: segregation analysis of 200 Danish pedigrees. Genet Epidemiol 1:7–20PubMedCrossRefGoogle Scholar
  22. Yeung KS (1983) Epidemiology of breast cancer among Chinese women in the San Francisco Bay. PhD Dissertation, University of CaliforniaGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • N. Andrieu
    • 1
  • F. Clavel
    • 1
  • F. Demenais
    • 2
  1. 1.Unité de recherche en epidémiologie des cancers, INSERM U287Institut Gustave RoussyVillejuif CedexFrance
  2. 2.Howard University Cancer CenterUSA

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