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Clonality of Post-transplant Lymphoproliferative Diseases

  • Conference paper
Cancer in Organ Transplant Recipients

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Abstract

The Epstein-Barr virus (EBV) is a unique DNA virus with infectious and oncogenic properties. EBV infects and transforms human or primate B lymphocytes bearing EBV membrane receptors (Jondal and Klein 1973) resulting in a polyclonal activation in vitro (Rosen et al. 1977; Kirchner et al. 1979). EBV causes infectious mononucleosis in man, a benign, selflimited, polyclonal B cell hyperplasia (Robinson et al. 1980; Henle and Henle 1979; Brown et al. 1986), and has also been implicated as a critical cofactor, along with certain nonrandom chromosomal alterations, in the development of African Burkitt’s lymphoma (BL), a monoclonal B cell proliferation (Lenoir 1986).

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References

  • Arnold A, Cossman J, Bakhshi A, Jaffe ES, Waldmann TA, Korsmeyer SJ (1983) Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. N Engl J Med 309:1593–1600

    Article  PubMed  CAS  Google Scholar 

  • Bakhshi A, Minowada J, Arnold A et al. (1983) Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors. N Engl J Med 309:826–831

    Article  PubMed  CAS  Google Scholar 

  • Bieber CP, Heberling RL, Jamieson SW et al. (1984) Lymphoma in cardiac transplant recipients associated with cyclosporin A, prednisone and anti-thymocyte globulin (ATG). In: Purtilo DT (ed) Immune deficiency and cancer. Plenum New York, pp: 309–320

    Google Scholar 

  • Brown NA, Liu C, Garcia CR et al. (1986) Clonal origins of lymphoproliferative disease induced by Epstein-Barr Virus. J Virol 58:975–978

    PubMed  CAS  Google Scholar 

  • Cleary ML, Sklar J (1984) Lymphoproliferative disorders in cardiac transplant recipients are multiclonal lymphomas. Lancet 2:489–493

    Article  PubMed  CAS  Google Scholar 

  • Cleary ML, Warnke R, Sklar J (1984) Monoclonality of lymphoproliferative lesions in cardiac-transplant recipients: clonal analysis based on immunoglobulin-gene rearrangements. N Engl J Med 310:477–482

    Article  PubMed  CAS  Google Scholar 

  • Ford AM, Molgaard HV, Greaves MF, Gould HJ (1983) Immunoglobulin gene organization and expression in hematopoietic stem cell leukemia. EMBO J 2:997–1002

    PubMed  CAS  Google Scholar 

  • Frizzera G, Hanto DW, Gajl-Peczalska KJ et al. (1981) Polymorphic diffuse B-cell hyperplasias and lymphomas in renal transplant recipients. Cancer Res 41:4262–4279

    PubMed  CAS  Google Scholar 

  • Hanto DW, Frizzera G, Purtilo DT et al. (1981) Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus. Cancer Res 41:4253–4261

    PubMed  CAS  Google Scholar 

  • Hanto DW, Frizzera G, Gajl-Peczalska KJ et al. (1982) Epstein-Barr virus-induced B-cell lymphoma after renal transplantation: acyclovir therapy and transition from polyclonal to monoclonal B-cell proliferation. N Engl J Med 306:913–918

    Article  PubMed  CAS  Google Scholar 

  • Hanto DW, Gajl-Peczalska KJ, Frizzera G et al. (1983) Epstein-Barr virus (EBV) induced polyclonal and monoclonal B-cell lymphoproliferative diseases occurring after renal transplantation. Ann Surg 198:356–369

    Article  PubMed  CAS  Google Scholar 

  • Hanto DW, Frizzera G, Gajl-Peczalska KJ, Simmons RL (1985) Epstein-Barr virus, immunodeficiency, and B cell lymphoproliferation. Transplantation 39:461–472

    Article  PubMed  CAS  Google Scholar 

  • Hanto DW, Birkenbach M, Frizzera G, Gajl-Peczalska KJ, Simmons RL, Schubach WH (1989) Confirmation of the heterogeneity of posttransplant Epstein-Barr virus-associated B cell proliferations by immunoglobulin gene rearrangement analysis. Transplantation 47:458–464

    Article  PubMed  CAS  Google Scholar 

  • Henle G, Henle W (1979) The virus as the etiologic agent of infectious mononucleosis. In: Epstein MA, Achong BG (eds) The Epstein-Barr virus. Springer Berlin Heidelberg New York, pp 297–320

    Chapter  Google Scholar 

  • Hozir JC, Lidquist LL (1980) Banded karotypes from bone marrow: a clinically useful approach. Hum Genet 53:205–209

    Google Scholar 

  • Jondal M, Klein G (1973) Surface markers on human B and T lymphocytes: II Presence of Epstein-Barr virus receptors on B lymphocytes. J Exp Med 138: 1365–1378

    Article  PubMed  CAS  Google Scholar 

  • Kirchner H, Tosato G, Blaese RM, Broder S, Magrath IT (1979) Polyclonal immunoglobulin secretion by human B lymphocytes exposed to Epstein-Barr virus in vitro. J Immunol 122:1310–1313

    PubMed  CAS  Google Scholar 

  • Klein G (1979) Lymphoma development in mice and humans; diversity of initiation is followed by convergent cytogenetic evolution. Proc Natl Acad Sci USA 76: 2442–2446

    Article  PubMed  CAS  Google Scholar 

  • Korsmeyer SJ, Hieter PA, Shanow SO, Goldman CK, Leder P, Waldmann JA (1982) Normal human B cells display ordered light chain rearrangements and deletions. J Exp Med 156:975–985

    Article  PubMed  CAS  Google Scholar 

  • Korsmeyer SJ, Arnold A Bakhshi A et al. (1983) Immunoglobulin gene arrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. J Clin Invest 71:301–313

    Article  PubMed  CAS  Google Scholar 

  • Lenoir GM (1986) Role of the virus, chromosomal translocations and cellular oncogenes in the aetiology of Burkitt’s lymphoma. In: Epstein MA, Achong BG (eds) The Epstein-Barr virus: recent advances. Wiley New York, pp 183–205

    Google Scholar 

  • Reece ER, Gartner JG, Seemayer TA, Joncas JH, Pagano JS (1981) Epstein-Barr virus in a malignant lymphoproliferative disorder of B-cells occurring after thymic epithelial transplantation for combined immunodeficiency. Cancer Res 41:4243–4247

    PubMed  CAS  Google Scholar 

  • Robinson JE, Brown JE, Andiman W et al. (1980) Diffuse polyclonal B-cell lymphoma during primary infection with Epstein-Barr virus. N Engl J Med 302: 1293–1297

    Article  PubMed  CAS  Google Scholar 

  • Rosen A, Gergely P, Jondal M, Klein G, Britton S (1977) Polyclonal Ig production after Epstein-Barr virus infection of human lymphocytes in vitro. Nature 267: 52–54

    Article  PubMed  CAS  Google Scholar 

  • Saemundsen AK, Berkel AI, Henle W et al. (1981) Epstein-Barr virus DNA in a patient with ataxia-telangiectasia. Br Med J (Clin Res) 282:425–427

    Article  CAS  Google Scholar 

  • Schubach WH, Hackman R, Neiman PE, Miller G, Thomas ED (1982) A monoclonal immunoblastic sarcoma in donor cells bearing Epstein-Barr virus genomes following allogeneic marrow grafting for acute lymphoblastic leukemia. Blood 60:180–187

    PubMed  CAS  Google Scholar 

  • Starzl TE, Nalesnik MA, Porter KA et al. (1984) Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet 1:583–587

    Article  PubMed  CAS  Google Scholar 

  • Sullivan JL (1983) Epstein-Barr virus and the X-linked lymphoproliferative syndrome. Adv Pediatr 30:365–399

    PubMed  CAS  Google Scholar 

  • Weintraub J, Warnke RA (1982) Lymphoma in cardiac allotransplant recipients: clinical and histological features and immunological phenotype. Transplantation 33:347–351

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. D. W. Hanto
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Editors and Affiliations

  1. Institut für Toxikologie und Chemotherapie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, W-6900, Heidelberg, Germany

    Dietrich Schmähl

  2. Medical Center, College of Medicine, Department of Surgery, Unviersity of Cincinnati, 231, Bethesda Avenue, Cincinnati, OH, 45267, USA

    Israel Penn

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© 1991 Springer-Verlag Berlin Heidelberg

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Hanto, D.W. (1991). Clonality of Post-transplant Lymphoproliferative Diseases. In: Schmähl, D., Penn, I. (eds) Cancer in Organ Transplant Recipients. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75991-8_4

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  • DOI: https://doi.org/10.1007/978-3-642-75991-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53020-6

  • Online ISBN: 978-3-642-75991-8

  • eBook Packages: Springer Book Archive

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