Malignancies in Man After Organ Transplantation
Even before the question could be studied in man, an increased incidence of cancer in organ transplant recipients was implied by the immunosurveillence hypothesis proposed by Thomas (1959) and Burnet (1965). Their predictions have been amply confirmed by observations since then, but in ways that have helped to modify the original theory. These observations have come from follow-up studies of transplant recipients, together with details of malignancies collected from around the world by Penn. The findings, briefly reviewed here, are of both clinical and scientific interest.
KeywordsLymphoma Sarcoma Cardiomyopathy Cyclosporine Cyclophosphamide
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