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Possible Causes of Cancer in Transplant Patients

  • Conference paper
Cancer in Organ Transplant Recipients

Abstract

Multiple factors probably play a role in the etiology of the various cancers that occur post-transplantation (Penn 1986, 1988, 1989). Immunodeficiency per se and infection with oncogenic viruses are probably the major influences. In this chapter we shall discuss their roles and also those of the underlying diseases requiring transplantation; direct damage to DNA by various immunosuppressive treatments; possible synergistic effects of these treatments with various carcinogens; other potentially carcinogenic treatments given to the patients; and genetic factors influencing susceptibility or resistance to the development of malignancy.

This work was supported in part by a grant from the Department of Veterans Affairs.

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  1. I. Penn
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Editors and Affiliations

  1. Institut für Toxikologie und Chemotherapie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, W-6900, Heidelberg, Germany

    Dietrich Schmähl

  2. Medical Center, College of Medicine, Department of Surgery, Unviersity of Cincinnati, 231, Bethesda Avenue, Cincinnati, OH, 45267, USA

    Israel Penn

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© 1991 Springer-Verlag Berlin Heidelberg

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Penn, I. (1991). Possible Causes of Cancer in Transplant Patients. In: Schmähl, D., Penn, I. (eds) Cancer in Organ Transplant Recipients. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75991-8_14

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  • DOI: https://doi.org/10.1007/978-3-642-75991-8_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53020-6

  • Online ISBN: 978-3-642-75991-8

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