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Immune Response Directed Against Epstein-Barr Virus Carrier B Lymphocytes

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Cancer in Organ Transplant Recipients

Abstract

In children infection with the Epstein-Barr virus (EBV) occurs usually unnoticed. About half of the individuals infected during and after adolescence may suffer the syndrome of infectious mononucleosis (IM). In both cases the conversion to seropositivity indicates the acquisition of the virus, which is thereafter harbored in the B lymphocytes and in the epithelial cells of the oropharynx. The latter cells permit the productive cycle, with the result that infectious particles enter into the saliva and are responsible for the oral virus spread. The virus can be detected in biological assays such as infection and immortalization of B cells in culture. The details of EBV infection, the cell-virus and host-virus interactions, have been extensively studied, (for reviews see: Epstein and Achong 1979, 1986; Klein 1989a). On the basis of the available facts, the scenario of the virus infection and its consequences can be largely envisaged. However there are still important basic events which have not been clarified.

This work was supported by the Swedish Cancer Society, by Public Health Service grant No 5 R01 CA 25250–11, awarded by the National Cancer Institute, DHHS, by the Bristol Myers Company, the Cancer Institute, New York, and the Concern Foundation, Los Angeles.

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  1. E. Klein
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  1. Institut für Toxikologie und Chemotherapie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, W-6900, Heidelberg, Germany

    Dietrich Schmähl

  2. Medical Center, College of Medicine, Department of Surgery, Unviersity of Cincinnati, 231, Bethesda Avenue, Cincinnati, OH, 45267, USA

    Israel Penn

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Klein, E. (1991). Immune Response Directed Against Epstein-Barr Virus Carrier B Lymphocytes. In: Schmähl, D., Penn, I. (eds) Cancer in Organ Transplant Recipients. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75991-8_11

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  • DOI: https://doi.org/10.1007/978-3-642-75991-8_11

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