Human Papillomaviruses

  • E.-M. de Villiers
Conference paper


Over the last decade it has become evident that the human papillomaviruses (HPV) represent a group of viruses which all comprise an 8-kb double-stranded DNA molecule packed in a spherical, icosahedral capsid of 45–55 nm in diameter. The papillomavirus DNA encodes for a number of early proteins, as well as for two late genes, L1 and L2. The capsid is constituted of these late proteins and probably of one of the so-called early proteins, E4 (Doorbar et al. 1986; Breitburd et al. 1987). The early proteins all have different functions within the host cell (Spalholz and Howley 1989). The E1 has been shown in the bovine papillomavirus (BPV) to be responsible for maintaining the episomal state of the DNA molecule. The E2 and the non-coding or regulatory region of the viral DNA exert a controlling function on the transcription of the other genes (Phelps and Howley 1987; Cripe et al. 1987; Lambert et al. 1990). The E6 and E7 genes of certain types of genital HPVs and BPV (and the E5 gene of BPV) code for proteins capable of transforming rodent cells (Kanda et al. 1988; Bedell et al. 1987), and the E6–E7 region of certain HPVs immortalize human keratinocytes (Bedell et al. 1989; Phelps et al. 1988, Crook et al. 1989; Duerst et al. 1987; Pirisi et al. 1987; Kaur and McDougall 1988).


Human Papilloma Virus Laryngeal Carcinoma Verrucous Carcinoma Tongue Carcinoma Inverted Papilloma 
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© Springer-Verlag Berlin Heidelberg 1991

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  • E.-M. de Villiers

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