Abstract
High-energy shock waves (HESW) can alter the growth characteristics of tumor cells in vitro, depending on the experimental set-up (Brümmer et al. 1989). Furthermore, treatment with HESW can provoke suppression of tumor growth in vivo (Holmes et al. 1990; Randazzo et al. 1988; Russo et al. 1985, 1986). Our own experiments with several tumor model systems have confirmed this observation. The in vivo antitumor effect of HESW depends on the number of shock waves, the number of shock wave sessions, the initial tumor burden, and the tumor model used (Oosterhof et al. 1990). The observed tumor growth suppression in vivo is temporary and results rather in an elongated lag phase than in a permanent effect. This indicates that HESW treatment is not likely to be useful as monotherapy, and in order to obtain a longer and more definite suppression of tumor growth HESW should be combined with other treatment modalities. We therefore decided to treat the xenograft tumors with additional therapies which are known to be suboptimal. In this study we tested established tumors, known to be partially or completely insensitive to monotherapies (Beniers et al. 1988), with a combination of HEWS and either the chemotherapeutic drug doxorubicin or biological response modifier (BRM) therapy with TNFα/IFNα.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Beniers AJMC, van Moorselaar RJA, Peelen WP, Debruyne FMJ, Schalken JA (1988) Differential sensitivity of renal xenografts towards therapy with interferon-α, interferon-γ, tumor necrosis factor and their combinations; possible implications for clinical studies. Urol Res (in press).
Berens ME, Welander CE, Griffin AS, McCullough DL (1989) Effect of acoustic shock waves on clonogenic growth and drug sensitivity of human tumor cells in vitro. J Urol 142:1090–1094.
Brendel W, Delius M, Goetz A (1987) Effect of shock waves on microvasculature. Prog Appl Microcirc 12:41–50.
Brümmer F, Brenner J, Bräuner T, Hülser DF (1989) Effects of shock waves on suspended and immobilized L1210 cells. Ultrasound Med Biol 15:229–329.
Goetz AE, Konigsberger R, Hammersen F, Conzen P, Delius M, Brendel W (1988) Acute shock wave induced effects on the microcirculation. In: Steiner R (ed) Laser lithotripsy. Springer, Berlin Heidelberg New York Tokyo.
Holmes RP, Yeaman LI, Li W, Hart LJ, Wallen CA, Woodruff RD, McCullough DL (1990) The combined effects of shock waves and cisplatin therapy on rat prostate tumors. J Urol 144:159–163.
Laudone VP, Morgan TR, Huryk RF, Heston WDW, Fair WR (1989) Cytotoxicity of high energy shock waves: methodologic considerations. J Urol 141:965–968.
Oosterhof GON, Smits GAHJ, de Ruyter JE, van Moorsealaar RJA, Schalken JA, Debruyne FMJ (1989) The in vitro effect of electromagnetically generated shock waves (Lithostar) on the Dunning R3327 PAT-2 rat prostatic cancer cell line. Urol Res 17:13–19.
Oosterhof GON, Smits GAHJ, de Ruyter JE, Schalken JA, Debruyne FMJ (1990) In vivo effects of high energy shock waves on urological tumors; an evaluation of treatment modalities. J Urol 144:785–789.
Oosterhof GON, Smits GAHJ, de Ruyter JE, Schalken JA, Debruyne FMJ (1990) Effects of high energy shock waves combined with biological response modifiers or adriamycin on a human kidney cancer xenograft. Urol Res (in press).
Oosterhof GON, Smits GAHJ, de Ruyter JE, Schalken JA, Debruyne FMJ (1990) Effects of high energy shock waves combined with biological response modifiers in different human kidney cancer xenografts. Ultrasound Med Biol (in press).
Randazzo RF, Chaussy CG, Fuchs GJ, Bhuta SM, Lovrekovich H, de Kernion JB (1988) The in vitro and in vivo effects of extracorporal shock waves on malignant cells. Urol Res 16:419–424.
Russo P, Heston WDW, Fair WR (1985) Suppression of in vitro and in vivo tumor growth by high energy shock waves. Surg Forum 36:645–648.
Russo P, Stephenson RA, Mies C, Huryk R, Heston WDW, Melamed MR, Fair WR (1986) High energy shock waves suppress tumor growth in vitro and in vivo. J Urol 135:626–628.
Shine N, Palladipp MA, Patton JS, Deisseroth A, Karczmar GB, Matson GB, Weiner MW (1989) Early metabolic response to tumor necrosis factor in mouse sarcoma: a phosphorus-31 nuclear magnetic resonance study. Cancer Res 49:2123–2127.
Smits GAHJ, Oosterhof GON, de Ruyter JE, Schalken JA, Debruyne FMJ (1990) Cytotoxic effects of high energy shock waves in different model systems: influence of the experimental set-up. J Urol 144 (in press).
Smits GAHJ, Heerschap A, Oosterhof GON, Debruyne FMJ, Ruys JHJ, Hilbers CW, Schalken JA (1990) Early metabolic response to high energy shock waves in a human tumor kidney xenograft monitored by 31 magnetic resonance spectroscopy (submitted).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Smits, G.A.H.J., Oosterhof, G.O.N., de Ruyter, A.E., Schalken, J.A., Debruyne, F.M.J. (1991). Antitumor Effects of High-Energy Shock Waves are Potentiated by Doxorubicin and Biological Response Modifiers. In: Jocham, D., Thüroff, J.W., Rübben, H. (eds) Investigative Urology 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75972-7_36
Download citation
DOI: https://doi.org/10.1007/978-3-642-75972-7_36
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-75974-1
Online ISBN: 978-3-642-75972-7
eBook Packages: Springer Book Archive