Effects of Isoprenaline, Papaverine and Verapamil on Rate Isolated Bladder Muscle

  • W. Diederichs
  • L. Hertle
  • H. Nawrath
Conference paper

Abstract

In general the mechanical activity of smooth muscles is determined by the concentration of free intracellular calcium. In relaxed smooth muscle, the intracellular calcium concentration is kept low. Two integrated membrane systems, the cell membrane and the sarcoplasmic reticulum, are involved in the control of the free intracellular calcium concentration (van Breemen). On bladder smooth muscle these conditions are still undergoing research. Of clinical importance in some urological disorders are drugs which induce relaxation of bladder smooth muscle and that means reduction of the free intracellular calcium concentration.

Keywords

Hydrochloride Catecholamine Verapamil Phosphodiesterase Carbachol 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • W. Diederichs
    • 1
  • L. Hertle
    • 1
  • H. Nawrath
    • 2
  1. 1.Urologische Klinikder Universität BochumHerne 1Germany
  2. 2.Pharmakologisches Institut der UniversitätMainzGermany

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