Tumour Induction at Ureterosigmoid Anastomosis without Faecal Stream: An Experimental Study

Abstract

To date there have been more than 100 case reports describing the occurrence of malignant tumours after ureterosigmoidostomy performed after benign primary disease. It is beyond doubt that this kind of supravesical urinary diversion may lead to tumour induction (Bristol and Williamson 1981; Miersch et al. 1989; Miersch 1990; Urdameta et al. 1966). However, induction of malignant tumours has also been observed after other forms of urinary diversion with bowel segments. Tumours have been found in colocystoplasties, ileocystoplasties, in a rectal bladder, and also in colon and ileal conduits (Chiang et al. 1982; Shousha et al. 1978). Here, in these urinary diversions without faecal stream, postoperative care with regard to the possible induction of tumour is by no means general. To determine the possible risk, we decided to examine whether induction of tumour at the site of anastomosis is possible without faecal stream, and, if so, to what extent it is possible.

Supported by a grant from the Dr. Mildred Scheel Foundation for Cancer Research, FRG