Abstract
The diagnosing of early stage cancer on the basis of detection of systemically applied fluorescing porphyrin compounds is attracting growing interest. Porphyrin derivative-induced fluorescence was initially used for visualization of mainly experimental tumors and highly proliferating neoplasms (Figge et al. 1948). Improved tumor markers and sensitive fluorescence detection devices allow endoscopic administration to various hollow organs such as lung (Kato et al. 1990; Lam et al. 1990) and esophagus (Monnier et al. 1990). In regard to the bladder, histopathologic examination of resected specimens confirmed the correlation of fluorescence intensity with tumorous sites (Benson et al. 1982). In this paper, first clinical experiences with fluorescence imaging of cancerous lesions of the bladder are reported.
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References
Baumgartner R, Fisslinger H, Jocham D, Lenz H, Ruprecht L, Stepp H, Unsöld E (1987) A fluorescence imaging device for endoscopic detection of early stage cancer — instrumental and experimental studies. Photochem Photobiol 46:5.
Benson RC Jr, Farrow GM, Kinsey JH et al. (1982) Detection and localization of in situ carcinoma of the bladder with hematoporphyrin derivative. Mayo Clin Proc 548–555.
Figge FHJ, Weiland GS, Manganiello LOJ (1948) Cancer detection and therapy. Affinity of neoplastic, embryonic, and traumatized tissues for porphyrins and metalloporphyrins. Proc Soc Exp Biol Med 68:640–641.
Lam S, Hung J, Palcic B (1990) Detection of lung cancer by ratio fluorometry with and without Photofrin II. SPIE Optic Fibers Med 1201:561–568.
Manyak MJ, Russo A, Smith PD, Glatstein E (1988) Photodynamic therapy. J Clin Oncol 6:380–391.
Monnier P, Savary M, Fontolliet C, Wagnieres G, Chatelain A, Cornaz P, Depeursinge C, Van den Bergh H (1990) Photodetection and photodynamic therapy of “early” squamous cell carcinomas of the pharynx, oesophagus and tracheo-bronchial tree. Lasers Med Sci 5:149–169.
Kato H, Imaizumi T, Aizawa K, Iwabuchi H, Yamamoto H, Ikeda N, Tsuchida T, Tamachi Y, Ito T, Hayata Y (1990) Photodynamic diagnosis in respiratory tract malignancy using an excimer dye laser system. J Photochem Photobiol B 6:189–196.
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© 1991 Springer-Verlag Berlin Heidelberg
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Baumgartner, R. et al. (1991). First Clinical Experiences with Photodynamic Fluorescence Diagnosis in Urology. In: Jocham, D., Thüroff, J.W., Rübben, H. (eds) Investigative Urology 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75972-7_17
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DOI: https://doi.org/10.1007/978-3-642-75972-7_17
Publisher Name: Springer, Berlin, Heidelberg
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