31 NMR In Vivo Studies of Human Renal Cell and Transitional Cell Carcinomas Xenografted into Nude Mice

  • S. Pomer
  • A. C. Küsel
  • G. Staehler
  • W. E. Hull
Conference paper

Abstract

31 P NMR is of particular interest for tumor investigations, since various neoplasms can differ from normal cells in pH, energy metabolism, and phospholipid turnover (proliferation rate). Human tumor cells can be studied as cultures in an appropriate matrix or as solid tumors (xenografts) in the nude mouse.

Keywords

Cage Interferon Hull Phospho Diester 

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References

  1. Daly PF, Cohen JS (1989) Magnetic resonance spectroscopy of tumors and potential in-vivo clinical applications: a review. Cancer Res 49:770–779.PubMedGoogle Scholar
  2. Hull WE, Kuesel AC, Graschew G, Lorenz W, Thielmann HW (1990) High-field 31P NMR studies of several human tumor cell lines. Comparisons in basement membrane gel culture and in solid tumors (abstracts). Magn Reson Med 9:845.Google Scholar
  3. Steen RG (1989) Response of solid tumors to chemotherapy monitored by in-vivo 31P nuclear magnetic resonance spectroscopy: a review. Cancer Res 49:4075–4085.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • S. Pomer
    • 1
  • A. C. Küsel
    • 2
  • G. Staehler
    • 1
  • W. E. Hull
    • 2
  1. 1.Abt. Urologie und PoliklinikChirurgische UniversitätsklinikHeidelbergGermany
  2. 2.Zentrale SpektroskopieDKFZHeidelbergGermany

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