Myelodysplastic Syndromes in Childhood: Description of 11 Cases

  • E. T. van’t Veer-Korthof


Myelodysplastic syndrome (MDS) does occur in childhood, although much less often than in adulthood. The pediatrician may be confronted with children with bi- or pancytopenia whose illness either does not completely fulfill the criteria for aplastic anemia (AA) or has an extra laboratory abnormality which does not fit into the diagnosis AA. Since the description of MDS in the literature (1982) [1], many of these aplasia-like syndromes appear to fit into the MDS classification. MDS occurs in previously healthy children as well as in children with Down’s syndrome and Fanconi anemia. Therapy-related MDS, occurring before the age of 18 years, has not been described.


Bone Marrow Transplantation Aplastic Anemia Myelodysplastic Syndrome Fanconi Anemia Allogeneic Bone Marrow Transplantation 
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  1. 1.
    Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1982) Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 51: 189–199PubMedGoogle Scholar
  2. 2.
    van der Does-van den Berg A, Hählen K, Colly LP, Vossen JM (1988) Treatment of childhood acute non-lymphocytic leukemia with high-dose cytosine arabinoside, 6-thioguanine and doxorubicin without maintenance therapy. Pediatr Hematol Oncol 5: 93–102Google Scholar

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© Springer-Verlag Berlin Heidelberg 1992

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  • E. T. van’t Veer-Korthof

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