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Generalized Lymphadenopathy in Juvenile Chronic Myelomonocytic Leukemia Is Due to Lymph Node Infiltration with Myelomonocytic Cells and Immature T Cells

  • O. A. Haas
  • A. Zoubek
  • U. Köller
  • A. Martins da Cuñha
  • T. Radaszkiewicz
  • C. R. Bartram
  • I. Mutz
  • H. Gadner
Conference paper

Abstract

Juvenile chronic myelomonocytic leukemia (JCMML) is a rare disease in young children which is currently classified as a myelodysplastic syndrome (MDS). It is characterized clinically by hepato- and splenomegaly, generalized lymphadenopathy, facial rash, thrombocytopenia, and an increase in mature and immature monocytes in peripheral blood (PB) and bone marrow (BM) [1]. A combination of these and other established diagnostic criteria allow its delineation from other forms of MDS and the, in children even rarer, form of Philadelphia chromosome (Ph) negative chronic myeloid leukemia.

Keywords

Chronic Myeloid Leukemia Blast Crisis Hemophagocytic Lymphohistiocytosis Secondary Follicle Generalize Lymphadenopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • O. A. Haas
    • 1
  • A. Zoubek
    • 1
  • U. Köller
    • 2
  • A. Martins da Cuñha
    • 1
  • T. Radaszkiewicz
    • 3
  • C. R. Bartram
    • 4
  • I. Mutz
    • 5
  • H. Gadner
    • 1
  1. 1.Children’s Cancer Research InstituteSt. Anna Children’s HospitalViennaAustria
  2. 2.Institute for Clinical Chemistry and Laboratory Medicine and Institute of ImmunologyUniversity of ViennaViennaAustria
  3. 3.Institute of PathologyUniversity of ViennaAustria
  4. 4.Section of Molecular Biology, Department of Pediatrics IIUniversity UlmUlmGermany
  5. 5.LandeskrankenhausLeobenAustria

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