Generalized Lymphadenopathy in Juvenile Chronic Myelomonocytic Leukemia Is Due to Lymph Node Infiltration with Myelomonocytic Cells and Immature T Cells
Juvenile chronic myelomonocytic leukemia (JCMML) is a rare disease in young children which is currently classified as a myelodysplastic syndrome (MDS). It is characterized clinically by hepato- and splenomegaly, generalized lymphadenopathy, facial rash, thrombocytopenia, and an increase in mature and immature monocytes in peripheral blood (PB) and bone marrow (BM) . A combination of these and other established diagnostic criteria allow its delineation from other forms of MDS and the, in children even rarer, form of Philadelphia chromosome (Ph) negative chronic myeloid leukemia.
KeywordsLymphoma Leukemia Agarose Influenza Germinal
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