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Maturation Pattern and Evolution of Leukemia in the Myelodysplastic Syndrome

  • P. Dörmer
Conference paper

Abstract

In a cell-kinetic study of a patient with preleukemia who developed overt acute myeloid leukemia (AML) 2 years later we were able to show that the essential kinetic abnormalities of AML were already present in the preleukemic state [4]. With the data of this patient a model was developed that conceived the progression of leukemia in this case as a continuous process from the first observation on without any further transformational event taking place during preleukemia [3]. A prospective study of MDS was performed to verify whether this observation represented a general rule or only an exception. A report on chromosomal findings in myelodysplastic syndromes (MDS) by Tricot et al. [14] suggested that both types of leukemic evolution may indeed be found, although no detailed data were provided. The evaluations of this prospective study have recently been communicated in detail [5–7] and are summarized in this report.

Keywords

Acute Myeloid Leukemia Bone Marrow Cell Myelodysplastic Syndrome Actuarial Survival Refractory Anemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • P. Dörmer

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