Maturation Pattern and Evolution of Leukemia in the Myelodysplastic Syndrome
In a cell-kinetic study of a patient with preleukemia who developed overt acute myeloid leukemia (AML) 2 years later we were able to show that the essential kinetic abnormalities of AML were already present in the preleukemic state . With the data of this patient a model was developed that conceived the progression of leukemia in this case as a continuous process from the first observation on without any further transformational event taking place during preleukemia . A prospective study of MDS was performed to verify whether this observation represented a general rule or only an exception. A report on chromosomal findings in myelodysplastic syndromes (MDS) by Tricot et al.  suggested that both types of leukemic evolution may indeed be found, although no detailed data were provided. The evaluations of this prospective study have recently been communicated in detail [5–7] and are summarized in this report.
KeywordsAcute Myeloid Leukemia Bone Marrow Cell Myelodysplastic Syndrome Actuarial Survival Refractory Anemia
Unable to display preview. Download preview PDF.
- 2.Dörmer P (1973) Kinetics of erythropoietic cell proliferation in normal and anemic man. A new approach using quantitative 14C-autoradiography. Progr Histochem Cytochem 6 ( 1 ): Fischer, StuttgartGoogle Scholar
- 3.Dörmer P (1979) How can we interpret the cell-kinetic status of preleukaemia? In: Preleukemia. Schmalzl F, Hellriegel KP (eds). Springer, Berlin, Heidelberg, New York, pp. 147–152Google Scholar