Zusammenfassung
In den letzten 10 Jahren hat sich durch die Entwicklung und den Einsatz moderner molekularbiologischer Methoden unser Wissen über die Ätiologie des Zervixkarzinoms wesentlich erweitert. Die entscheidende Entdeckung war der Nachweis von HPV-DNS in mehr als 90% der untersuchten Zervixkarzinome. HPV-Typen, die man in Zervixkarzinomproben oder CIN-III — Biopsien nachweisen kann, werden als Risikotypen betrachtet.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Literatur
Barten G (1990): Ultrastruktureller Papillomvirusnachweis bei Vor- und Frühstadien des Zervixkarzinoms. Zbl Gynäkol 112: 33–38
Boshart M, Gissmann L, Ikenberg H, Keinheinz A, Scheurlen W, Zur Hausen H (1984): A new type of papillomavirus DNA, its presence in genital cancer biopsies and cell lines derived from cervical cancer. EMBO 13: 1151–1157
De Villiers E-M (1989): Heterogeneity of the human papillomavirus group. J Virology 63: 4898–4903
De Villiers E-M, Schneider A, Miklaw H et al. (1987): Human papillomavirus infections in women with and without abnormal cervical cytology. Lancet 11: 703–705
Dürst M, Gissmann L, Ikenberg H, Zur Hausen H (1983): A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy sample from different geographic regions. Proc Natl Acad Sci USA 80: 3812–3815
Friedmann W, Schäfer A, Weyerstahl T (1989): HIV-Infektionen und zervikale Neoplasien. Geburtshilfe Frauenheilkd 49: 997–1000
Göppinger A, Ikenberg H, Birmelin G, Hilgarth M, Pfleiderer A, Hillemanns H-G (1988): CO2-Lasertherapie und HPV-Typisierung bei CIN-Verlaufsbeobachtungen. Geburtshilfe Frauenheilkd 48: 343–345
Koss GL (1989): The Papanicolaou Test for cervical cancer detection. A triumph and a tragedy. JAMA 261: 737–743
Koss GL, Durfee GR (1956): Unusual patterns of squamous epithelium of uterine cervix, cytologic and pathologic study of coilocytotic atypia. Am NY Acad Sci 63: 1245–1261
Kurman RJ, Schiffman MH, Lancaster WD, Reid R, Jenson AB, Temple GF, Lorincz (1988): Analysis of individual human papillomavirus types in cervical neoplasia: a possible role for type 18 in rapid progression. Am J Obstet Gynecol 159: 293–296
Maniatis T, Fritsch EF, Sambrock J (1982): Molecular cloning. A laboratory manual. Cold Spring Harbor Laboratory, New York
McNicole PJ, Guijon FB, Paraskevas M, Brunham RC (1989): Comparison of filter in situ deoxyribonucleic acid hybridisation with cytologic, colposcopic, and histopathologic examination for detection of human papillomavirus infection in women with intraepithelial neoplasia. Am J Obstet Gynecol 160: 265–270
Munoz N, Bosch FX, Jensen MO (1989): Human papillomavirus and cervical cancer. WHO—IARC Sci Publ 94, Lyon
Neumann R, Eggers HJ, Zippel HH et al.: Beitrag zur klinischen Relevanz des Nukleinsäurenach weises der humanen Papillomviren (HPV) in Abstrichzellen der Cervix uteri. Geburtshilfe Frauenheilkd 49: 11–16
Peto R, zur Hausen H (1986): Viral etiology of cervical cancer. Banbury Report Nr. 21, Cold Spring Harbor
Reid R (1987): Human Papillomvirus. Obstet Gynecol North Am 14 /2 407–430
Reid R, Campino MJ (1988): The biology and significance of human papillomavirus infections in the genital tract. Yale J Biol Med 61: 307–325
Richart RM (1989): Cause and management of cervical intraepithelial neoplasie. Cancer 60: 1951–1959
Ritter DB, Kadish AS, Vermund SH, Romney SL, Vallari D, Burk RD (1988): Detection of human papillomavirus deoxyribonucleic acid in exfoliated cervicovaginal cells as a pre-dictor of cervical neoplasia in a high-risk population. Am J Obstet Gynecol 159:1517–1525
Schneider A, Schuhmann R, De Villiers EM, Knauf W, Gissmann L (1986): Klinische Bedeutung von humanen Papilloma-Virus-(HPV)-Infektionen im unteren Genitaltrakt. Geburtshilfe Frauenheilkd 46: 261–266
Schneider A, Sterzik K, Buck G, De Villiers E-M (1988): Colposcopy is superior to cytology for the detection of early genital human papillomavirus infection. Obstet Gynecol 71: 236–241
Shope RE (1933): Infectious papillomatosis of rabbits. J Exp Med 58: 607–624
Syrjänen KJ, Gissmann L, Koss GL (1987): Papillomviruses and human diseases. Springer, Berlin Heidelberg New York Tokyo
Syrjänen KJ, Mäntyjärvi R, Saarikoski S (1988): Factors associated with progression of cervical human papillomavirus ( HPV) infections into caarcinoma in situ during a long- term prospective follow-up. Br J Obstet Gynecol 95: 1096–1102
Wagner D (1988): Papillomavirusinfektion und Zervix-Karzinom: Bedeutung für die gynäkologische Krebs Vorsorge. GBK-Mitt. dienst 16: 33–39
Wagner D, Ikenberg H, Böhm N, Gissmann L (1984): Identification of human papillomavirus in cervical swabs by Deoxyribonucleic acid in situ hybridisation. Obstet Gynecol 64: 767–772
Zur Hausen H (1976): Condylomata acuminata and human genital cancer, Cancer Res 36: 530
Zur Hausen H (1988) Papillomviruses in human cancer. Molecular Carcinogenesis 1: 147–150
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Elling, D. (1991). Humane Papillomviren (HPV). In: Das Zervixkarzinom. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75944-4_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-75944-4_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-52956-9
Online ISBN: 978-3-642-75944-4
eBook Packages: Springer Book Archive