The paternal genes are inherited, and from the standpoint of graft immunity the disease has the characteristics of a homograft tumor.
These tumors produce human chorionic gonadotropin (hCG), and the level of hCG is a valuable marker for diagnosis as well as for assessment of therapeutic effect and remission.
Chemotherapy is very effective, and even metastatic cases may be cured by chemotherapy alone.
The tumors apparently progress from hydatidiform mole to invasive mole to choriocarcinoma, and therfore by controlling the hydatidiform mole stage it is possible to detect early choriocarcinoma or even prevent its occurrence.
KeywordsCisplatinum Methotrexate Folic Acid Cyclophosphamide Etoposide
Unable to display preview. Download preview PDF.
- Acosta-Sison H (1967) Trophoblastic or chorionic tumors as observed in the Philippines. In: Holland JF, Hreshchyshyn MM (eds) Choriocarcinoma. Springer, Heidelberg Berlin New York, ( UICC Monograph Series, vol 3, pp 33–36 )Google Scholar
- Bagshawe KD (1969) Metastatic Choriocarcinoma. In: Choriocarcinoma. Edward Arnold, London, pp 93–103Google Scholar
- Bagshawe KD (1987) Chemotherapy and general treatment—current and future developments. In: Takagi S, Freidberg V, Haller U, Knapstein PG, Sevin BV (eds) Gynecologic oncology, surgery and urology. Central Foreign Books, Tokyo, pp 243–249Google Scholar
- Franke HR, Risse EKJ, Kenemans P, Vooijs GR, Stolk JG (1983) Epidemiologic features of hydatidiform mole in the Netherlands. Obsestet Gynecol 62: 613–616Google Scholar
- Hertz R (1967) Eight years experience with the chemotherapy of choriocarcinoma and related trophoblastic tumors in women. In: Holland JF, Hreshchyshyn MM (eds) Choriocarcinoma. Springer, Heidelberg Berlin New York (UICC Monograph Series, vol 3, pp 66–71 )Google Scholar
- Ishizuka N (1976) Studies on trophoblastic neoplasia. In: Hirayama T (ed) Cancer in Asia. University of Tokyo Press, Tokyo (Gann Monograph on Cancer Research No 18, pp 203–216 )Google Scholar
- Jacobs PA, Hassold TJ, Matsuyama AM, Newland IM (1978) Chromosome constitutions of gestational trophoblastic disease. Lancet II: 49Google Scholar
- Kaseki S (1974) Primary chemotherapy of trophoblastic disease—experience with 123 cases. Acta Obstet Gynecol Jpn 26: 1069–1076Google Scholar
- Kurman RJ, Young RH, Norris HJ, Main CS, Lawrence WD, Scully R (1984) Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor. Int J Gynecol Pathol 3: 101–121PubMedCrossRefGoogle Scholar
- McCorriston CC (1968) Racial incidence of hydatidiform mole. Am J Obstet Gynecol 101:377–382 Newlands ES (1982) New chemotherapeutic agents in the management of gestational choriocarcinoma. Semin Oncol 9: 239–243Google Scholar
- Park WW, Lees JC: Choriocarcinoma. A general review, with an analysis of 516 cases. Arch Path 49:73–104, 205–241 (1950)Google Scholar
- Registration Committee for Trophoblastic Disease of the Japan Society of Obstetrics and Gynecology (1982) Report of the Registration Committee for Trophoblastic Disease. Acta Obstet Gynecol Jpn 34: 1805–1812Google Scholar
- Registration Committee for Trophoblastic Disease of the Japan Society of Obstetrics and Gynecology (1987) Report of the Registration Committee for Trophoblastic Disease. Acta Obstet Gynecol Jpn 39: 871–880Google Scholar
- Report of a WHO scientific group (1983) Gestational trophoblastic disease. WHO technical report series 692, Geneva, pp 11–12Google Scholar
- Report on the study financially assisted by the Cancer Research Fund of the Ministry of Health and Welfare for the fiscal year 1980Google Scholar
- Sugiura M, Goto S, Saito M, Kato S, Hattori S, Tomoda Y (1988) Establishment and characterization of three new human gestational choriocarcinoma cell lines. Acta Obstet Gynecol Jpn 40: 1447–1454Google Scholar
- Teoh ES, Dawood MY, Ratnam SS (1971) Epidemiology of hydatidiform mole in Singapore. Am J Obstet Gynecol: 415–420Google Scholar
- Tomoda Y, Kaseki S, Goto S, Ishizuka T, Furuhashi Y, Kato S (1986) Approach for attaining complete cure of trophoblastic disease. In: Ichinoe K (ed) Trophoblastic disease. Igaku-Shoin, Tokyo, pp 111–120Google Scholar