Abstract
Probe specificity is a major challenge in polymerase chain reaction research. Avoiding sequences that code for cross-reactive amino acid sequences can reduce unspecific binding of design nucleic acid probes. Analyzing both amino and nucleic acid sequences of recently identified receptors of T-cells mediating experimental allergic encephalitis, a model disease for multiple sclerosis, we found analogies between human immuno-deficiency virus (HIV) and myelin basic protein (MBP), as well as MBP and MBP-reactive lymphocytes. We present a synopsis of seven linear nucleic acid epitopes potentially associated with nervous system cross-recognition.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Hahn BH, Gonda MA, Shaw GM, Popovic M, Hoxie JA, Gallo RC, Wong-Staal F (1985). Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III. Different viruses exhibit greatest divergence in their envelope genes, Proc Natl Acad Sci USA 82: 4813–4817
Bahraoui E, Clerget Raslain B, Granier C, Van Rietschoten J, Sabatier JM, Labbe-Julie C, Ceard B, Rochat H, Gluckman JC, Montagnier L (1989). Accessibility of the highly conserved amino- and carboxy-terminal regions from HIV-1 external envelope glycoproteins, AIDS Res Hum Retrovir 5(4): 451–63
Maddon PJ, Dalgleish AG, McDougal JS (1986). The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain, Cell 47: 637–648
Klatzmann D, Champagne E, Chamaret S, Gruest J, Guetard D, Hercend T, Gluckman, JC, Montagnier L (1984). T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV, Nature 312: 767–768
Lentz TL (1985). Rabies virus receptors, Trends Neurosci 8: 360–364
Co MS, Gaulton GM, Tominaga A, Homey CJ, Fields BN, Greene MI (1985). Structural similarities between the mammalian ß-adrenergic and reovirus type 3 receptors, PNAS USA 82: 5315–5318
Eppstein DA, Marsh YV, Schreiber AB, Newman SR, Todaro GJ, Nestor JJ Jr (1985). Epidermal growth factor receptor occupancy inhibits vaccinia virus infection, Nature 318:663–665
Fingeroth JD, Weis JJ, Tedder TF, Strominger JL, Biro PA, Fearon DT (1984). Epstein-Barr virus receptor of human B lymphocytes in the C3d Receptor CR2, PNAS USA 81: 4510–4514
Westarp ME, Vohl ML, Przuntek H, Wekerele H (1985). Experimental allergic encephalomyelitis transferred by myelin basic protein-specific permant rat Tline lymphocytes; a model system. MPG Annu Rep Clin Res 2: 9
Westarp ME, Wekerle H, Ben-Nun A, Cohen IR, Vohl ML, Przuntek H (1987). T-lymphocyte line mediated experimental allergic encephalomyelitis (T-EAE) — a pharmacological model for testing of immunosuppressive agents for the treatment of autoimmune central nervous system disease. J Pharm Exp Ther 242 (2): 614–620
Chluba J, Steeg Ch, Becker A, Wekerle H, Epplen JT (1989). T cell receptor ß chain usage in myelin basic protein-specific rat T lymphocytes, Eur J Immunol 19: 279–284
Westarp ME, Föhring B (1989). Enzephalitis-assoziierte Peptid- epitope — Möglichkeiten und Ansätze, Verh Dt Ges Neurol 5: 437–446
Gnann JW, McCormick JB, Mitchell S, Nelson JA, Oldstone MBA (1987). Synthetic peptide immunoassay distinguishes HIV type 1 and type 2 infections, Science 237: 1346–1352
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Westarp, M.E., Föhring, B. (1991). Nervous System Cross Reactivity Sequences. In: Rolfs, A., Schumacher, H.C., Marx, P. (eds) PCR Topics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75924-6_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-75924-6_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-52934-7
Online ISBN: 978-3-642-75924-6
eBook Packages: Springer Book Archive