Abstract
The gene products of the early region E1A of adenoviruses play an essential role in both productive infection and cellular transformation. During lytic cycle expression of functional E1A proteins are necessary for trans-activation of all other adenoviral genes [1, 6]. Additionally, the expression of some cellular genes are induced by E1A proteins [7, 13]. They are also able to repress enhancer-mediated gene expression [12, 14]. Introduction of region E1A into primary cells leads to immortalization and, in cooperation with oncogenes like adenovirus E1B or cellular H-ras, to complete transformation [5, 11].
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Brockmann, D., Tries, B., Esche, H. (1991). Expression of Adenovirus Type 12 13S Gene Product is Sufficient to Immortalize Primary Mouse Cells. In: Rolfs, A., Schumacher, H.C., Marx, P. (eds) PCR Topics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75924-6_42
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DOI: https://doi.org/10.1007/978-3-642-75924-6_42
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