Abstract
Intrinsic or aquired resistance to cytotoxic drugs is one of the major reasons which limits the effectiveness of the chemotherapy of cancer [1]. Prognosis will improve if adequate diagnostic means are available which allow the detection of drug-resistant cell clones during the initial staging and subsequent treatment of neoplasms. A particular challenge is the management of multidrug-resistance (MDR). In most cases the overexpression of P-glycoprotein (mdr1) is causative responsible for this complex phenotype of cross resistance to anthracyclines, epidophyllotoxins, Vinca alkaloids and of collateral sensitivity to steroids, cyclosporines and certain calcium channel blockers [2].
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© 1991 Springer-Verlag Berlin Heidelberg
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Hoof, T., Riordan, J.R., Tümmler, B. (1991). Quantitation of Mdr1 Transcript by PCR a Tool for Monitoring Drug Resistance in Cancer Chemotherapy. In: Rolfs, A., Schumacher, H.C., Marx, P. (eds) PCR Topics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75924-6_39
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DOI: https://doi.org/10.1007/978-3-642-75924-6_39
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-52934-7
Online ISBN: 978-3-642-75924-6
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