Advertisement

Virologie der HIV-Infektion: Neue Erkenntnisse und Methoden

  • L. Gürtler
  • F. Deinhardt
Conference paper

Zusammenfassung

Dieser Beitrag versucht, die für die Betreuer von Hämophilie-Patienten relevanten neuen Ergebnisse der Epidemiologie, Pathogenese und Diagnostik der HIV-Infektion zusammenzufassen.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Mann JM (1989) Global AIDS into the 1990s. An address presented 4 June 1989 at the V International Conference on AIDS, Montreal, Canada. World Health Organization, Geneva (1989), pp 1–7Google Scholar
  2. 2.
    Pokrovsky VV, Eramova EU (1989) Nosocomial outbreak of HIV infection in Elista, USSR. V International Conference on AIDS, Montreal, Canada. Abstract W.A.0.5 -und persönliche MitteilungGoogle Scholar
  3. 3.
    Gerberding JL (1986) Recommended infection control policies for patients with human immunodeficiency virus infection. New Engl J Med 315:1562–564PubMedCrossRefGoogle Scholar
  4. 4.
    Bachetti P, Moss AR (1989) Incubation period of AIDS in San Francisco. Nature 338:251–253CrossRefGoogle Scholar
  5. 5.
    Lui KJ, Darrow WW, Rutherford GW (1988) A model-based estimate of the mean incubation period for AIDS in homosexual men. Science 240:1333–1335PubMedCrossRefGoogle Scholar
  6. 6.
    Gürtler I, Hess F (1989) Pathogene Wirkung des humanen Immunschwächevirus. Fortschr Med 107:237–239PubMedGoogle Scholar
  7. 7.
    Gendelman HE, Orenstein JM, Baca LM, Weiser B, Burger H, Kalter DC, Meltzer MS (1989) The macrophage in the persistence and pathogenesis of HIV infection. AIDS 3:475–495PubMedCrossRefGoogle Scholar
  8. 8.
    Tyler DS, Nastala CL, Stanlex SD, Matthews TJ, Lyerly HK, Bolognesi DP, Weinhold KJ (1989) Gp120 specific cellular cytotoxicity in HIV-1 seropositive individuals. Evidence for circulating CD16+ effector cells armed in vivo with cytophilic antibody. J Immunol 142:1177–1182PubMedGoogle Scholar
  9. 9.
    Wahl LM, Corcoran ML, Pyle SW, Arthur LO, Bellan AH, Farrar WL (1989) Human immunodeficiency virus glycoprotein (gp120) induction of monocyte arachidonic acid metabolites and interleukin 1. Proc Natl Acad Sci 86:621–625PubMedCrossRefGoogle Scholar
  10. 10.
    Brennemen DE, Westbrook GL, Fitzgerald SP, Ennist DL, Elkins KL, Ruff MR, Pert CB (1988) Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide. Nature 335:639–642CrossRefGoogle Scholar
  11. 11.
    Chaput M, Claes V, Portelle D, Cludts I, Cravador A, Burny A, Gras H, Tartar A (1988) The neurotrophic factor neuroleukin is 90% homologous with phosphohexose isomerase. Nature 332:454–455PubMedCrossRefGoogle Scholar
  12. 12.
    Clapham PR, Weber JN, Whitby D, Mcintosh K, Dalgleish AG, Maddon PJ, Deen KC, Sweet RW, Weiss RA (1989) Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells. Nature 337:368–370PubMedCrossRefGoogle Scholar
  13. 13.
    Traunecker A, Schneider J, Kiefer H, Karjalainen K (1989) Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules. Nature 339:68–70PubMedCrossRefGoogle Scholar
  14. 14.
    Prince AM, Horowitz B, Baker L, Shulman RW, Ralph H, Valinsky J, Cundell A, Brotman B, Boehle W, Rey F, Piet M, Reesink H, Lelie N, Tersmette M, Miedema F, Barbosa L, Nemo G, Nastala CL, Allan JS, Lee RD, Eichberg JW (1988) Failure of a human immunodeficiency virus (HIV) immune globulin to protect chimpanzees against experimental challenge with HIV. Proc Natl Acad Sci 85:6944–6948PubMedCrossRefGoogle Scholar
  15. 15.
    Takeda A, Tuazon CU, Ennis FA (1988) Antibody enhanced infection by HIV-1 via Fc receptor mediated entry. Science 242:580–583PubMedCrossRefGoogle Scholar
  16. 16.
    Robinson EW, Montefiori DC, Mitchell WM, Prince AM, Alter HJ, Dreesman GR, Eichberg JW (1989) Antibody-dependent enhancement of human immunodeficiency virus type 1 (HIV-1) infection in vitro by serum from HIV-1 infected and passively immunized chimpanzees. Proc Natl Acad Sci 86:4710–4714PubMedCrossRefGoogle Scholar
  17. 17.
    Homsy J, Meyer M, Tateno M, Clarkson S, Levy JA (1989) The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells. Science 244:1357–1360PubMedCrossRefGoogle Scholar
  18. 18.
    Bolognesi DP (1989) Progress in vaccines against AIDS. Science 246:1233–1234PubMedCrossRefGoogle Scholar
  19. 19.
    Webster A, Cook DG, Emery VC, Lee CA, Grundy JE, Kernoff PBA, Griffiths PD (1989) Cytomegalovirus infection and progression towards AIDS in haemophiliacs with human immunodeficiency virus infection. Lancet ii:63–66CrossRefGoogle Scholar
  20. 20.
    Ward JW, Bush TJ, Perkins HA, Lieb LE, Allen JR, Goldfinger D, Samson SM, Perkowitz SH, Fernando LP, Holland PV, Kleinman SH, Grindon AJ, Garner JL, Rutherford GW, Holmberg SD (1989) The natural history of transfusion-associates infection with human immunodeficiency virus. New Engl J Med 321:947–952PubMedCrossRefGoogle Scholar
  21. 21.
    Goedert JJ, Kessler CM, Aledort LM, Biggar RJ, Andes WA, White GC, Drummond JE, Vaidya K, Mann DL, Eyster E, Ragni MV, Lederman MM, Cohen AR, Bray GL, Rosenberg PS, Friedman RM, Hilgartner MW, Blattner WA, Kroner B, Gail MH (1989) A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia. New Engl J Med 321:1142–1148CrossRefGoogle Scholar
  22. 22.
    Stein BS, Gowda SD, Lifson JD, Penhallow RC, Bensch KG, Engleman EG (1987) pH-independent HIV entry into CD4-positive cells via virus envelope fusion to the plasma membrane. Cell 49:659–668PubMedCrossRefGoogle Scholar
  23. 23.
    Ranki AM, Krohn M, Allain JP, Franchini G, Valle S, Antonen J, Leuther M, Krohn K (1987) Long latency precedes overt seroconversion in sexually transmitted human immunodeficiency virus infections. Lancet ii:589–593CrossRefGoogle Scholar
  24. 24.
    Ronde DA, Reiss P, Dekker J, Wolf FD, Hoek AVD, Wolfs T, Debouck C, Goudsmit J (1988) Seroconversion to HIV-1 negative regulation factor. Lancet ii : 574CrossRefGoogle Scholar
  25. 25.
    Farzadegan H, Polis MA, Wolinsky SM, Rinaldo CR, Sninsky JJ, Kwok S, Griffith RL, Kaslow RA, Phair JP, Polk BF, Saah AJ (1988) Loss of immunodeficiency virus type 1 (HIV-1) antibodies with evidence of viral infection in asymptomatic homosexual men: a report from the multicenter AIDS cohort study. Ann Intern Med 108:785–790PubMedGoogle Scholar
  26. 26.
    Farzadegan H, Polis M, Wolinsky S, Rinaldo C, Kaslow R, Phair J, Saah A, Kwok S, Sninsky JJ (1989) Seroreversions in human immunodeficiency virus (HIV) infection — in response. Ann Intern Med 110:947–948Google Scholar
  27. 27.
    Imagawa DT, Lee MH, Wolinsky SM, Sano K, Morales F, Kwok S, Sninsky JJ, Nishanian PG, Giorgi J, Fahey JL, Dudley J, Visscher B, Detels R (1989) Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods. New Engl Med 320:1458–1462CrossRefGoogle Scholar
  28. 28.
    Lee MH, Sano K, Morales FE, Imagawa DT (1987) Sensitive reverse transcriptase assay to detect and quantitate human immunodeficiency virus. J Clin Microbiol 25:1717–1721PubMedGoogle Scholar
  29. 29.
    Horsburgh CR, Ou CY, Holmber SD, Schochteman G, Jaffe HW, Lifson AR, Rutherford GW (1989) to the editor. New Engl J Med 321:1679Google Scholar
  30. 30.
    Horsburgh CR, Jason J, Longini IM, Mayer KH, Schochteman G, Rutherford GW, Seage GR, Ou CY, Holmberg SD, Schable C, Lifson AR, Ward JW, Evatt BL, Jaffe HW (1989) Duration of human immunodeficiency virus infection before detection of antibody. Lancet ii:637–640CrossRefGoogle Scholar
  31. 31.
    Imagawa DT, Lee MH, Visscher B, Dudley J, Detels R (1989) reply to the editor. New Engl J Med 321:1681CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • L. Gürtler
    • 1
  • F. Deinhardt
    • 1
  1. 1.MünchenGermany

Personalised recommendations