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Molekulargenetische Untersuchungen beim yon Willebrand-Syndrom

  • C. Mannhalter
  • S. Parzer
  • P. A. Kyrle
Conference paper

Zusammenfassung

Der von Willebrand-Faktor ist ein multimeres Glykoprotein, welches in der Hämostase zwei wichtige Funktionen erfüllt. Einerseits wird er zur Anlagerung der Plättchen an geschädigtes Endothel benötigt, andererseits bindet er sich an Gerinnungsfaktor VIII und stabilisiert diesen in der Zirkulation [1, 2]. Die Rezeptoren des von Willebrand-Faktors an der Plättchenoberfläche sind bekannt — es handelt sich dabei um die Plättchenglykoproteine Ib und IIb/IIIa [3, 4].

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • C. Mannhalter
    • 1
  • S. Parzer
    • 1
  • P. A. Kyrle
    • 1
  1. 1.WienGermany

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