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Vitamin E als Therapeutikum in der klinischen Dermatologie

  • J. Fuchs
  • R. Milbradt
Chapter

Zusammenfassung

Eine Literaturübersicht über die klinische Verwendung von alpha-Tocopherol (Vitamin E) in der Dermatologie wird vorgestellt. Nach einer kurzen Einführung in die Chemie und Pharmakologie des Tocopherols und einer Diskussion der antioxidativen, antiinflammatorischen, mesenchymalen, photopro- tektiven und membranmodulierenden Eigenschaften der Substanz wird die pathophysiologische Bedeutung des oxidativen Stress für das Hautorgan besprochen und die Rolle des Tocopherols in diesem Szenario diskutiert. Es folgt eine Zusammenfassung verschiedener Dermatosen, die mit teils wechselnden Erfolgsraten mit Tocopherol behandelt wurden. Am Beispiel des chronisch kutanen Lupus erythematodes erläutern wir detailliert die klinischen Erfolgsergebnisse und diskutieren mögliche Wirkungsmechanismen. Die kutanen und systemischen Nebenwirkungen einer Tocopherol-Therapie werden besprochen und ein ausführliches Literaturverzeichnis aufgeführt.

Summary

We have reviewed the literature about the clinical use of alpha-tocopherol (vitamin E) in dermatology. A short introduction is given on tocopherol chemistry and pharmacology. Pharmacodynamic aspects of tocopherol action, such as its antioxidant, anti-inflammatory, mesenchymal, photoprotectant and membrane modulating activities, are discussed. The significance of oxidative stress in skin pathology is outlined and a specific role that tocopherol may play in this szenario is suggested. We provide a summary of various skin diseases, which have been treated with some success with tocopherol. The clinical efficiency of tocopherol in treatment of chronic cutaneous lupus erythematodes is evaluted in detail and the mechanism of action is discussed. An analysis of its cutaneous and systemic side effects is given and an extensive list of references presented.

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© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • J. Fuchs
    • 1
  • R. Milbradt
    • 1
  1. 1.Zentrum der Dermatologie und Venerologie, Abteilung IIJohann Wolfgang Goethe Universität, FrankfurtFrankfurt/M 70Germany

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