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Morphologie, Biologie und Therapeutische Konsequenzen der atypischen Keimzellen des Hodens

  • F. B. Bannwart
  • C. Sigg
  • C. Hedinger
Chapter
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Zusammenfassung

Seit 15 Jahren sind atypische Keimzellen als Vorläuferzellen von Hodenkeimzelltumoren beim Erwachsenen bekannt. Sie werden von einzelnen Autoren als totipotente Ursprungszellen der Hodenkeimzelltumoren betrachtet. Während die Morphologie dieser Zellen gut charakterisiert ist, sind Daten über die Entstehung und die Steuerung des biologischen Verhaltens dieser Zellen noch unvollständig. Die in der Literatur bekannten Daten und Erfahrungen aus dem Zürcher Untersuchungsgut werden dargestellt und therapeutische Implikationen erläutert.

Summary

The so-called atypical germ cells have been known as precursors of germ cell tumors of the testis for 15 years. They are regarded by several authors as totipotential cells capable to form all kinds of testicular germ cell tumors. While morphology of these cells is well characterized, data concerning their histogenesis and their biological significance, however, are not fully recognized and remain to be completed. A review of literature concerning atypical germ cells and the frequency as well as the biological behaviour of these cells in our own biopsy material are presented, and therapeutical consequences are discussed.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • F. B. Bannwart
    • 1
  • C. Sigg
    • 1
    • 2
  • C. Hedinger
    • 1
  1. 1.Institut für Pathologie Stadtspital TriemliZürichDeutschland
  2. 2.Dermatologische Klinik Universitätsspital ZürichInstitut für Pathologie Universitätsspital ZürichZürichDeutschland

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