Selective Killing of IL6 Receptor Bearing Myeloma Cells Using Recombinant IL6-Pseudomonas Toxin

  • Clay B. Siegall
  • David J. FitzGerald
  • Ira Pastan
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 166)


Chemotherapy is widely used in the treatment of human cancer but unfortunately is not successful against many cancers and has undesirable side effects. If the chemotherapeutic agent was only delivered to the tumor cell, it should be possible to eliminate cancer cells without killing normal cell populations. Recently, a new field has emerged which addresses the possibility that one can selectively eliminate malignant cell populations. This new discipline takes advantage of the fact that many cancer cells display higher numbers of growth factor receptor on their surface than normal cells. By taking advantage of this increase, one can target these receptors with cytotoxic reagents such as protein toxins. These reagents are cytotoxic to target cells because a receptor specific ligand is linked to a potent toxin (reviewed in Pastan 1986; Vitetta 1987; FitzGerald and Pastan 1989). In this review, we will describe specific reagents which can target and kill multiple myeloma cells.


Clay Toxicity Filtration Carboxyl Interferon 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Clay B. Siegall
    • 1
  • David J. FitzGerald
    • 1
  • Ira Pastan
    • 1
  1. 1.Laboratory of Molecular Biology, Division of Cancer Biology and Diagnosis and CentersNational Cancer Institute, National Institutes of Health BethesdaUSA

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