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IL-6 Induces Hybridoma Cell Growth Through a Novel Signalling Pathway

  • Chapter
Mechanisms in B-Cell Neoplasia 1990

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 166))

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Abstract

With the successful cloning of Interleukin-6 (IL-6) (Haegeman et al. 1986; Hirano et al. 1986; Zilberstein et al. 1986), it became evident that a number of diverse physiological responses in different cell lineages were mediated by this single cytokine (for reviews, see (Kishimoto et al. 1988; Wong et al. 1988). IL-6 regulates the proliferation and the terminal differentiation of cells at different stages in the B cell lineage. IL-6 supports the growth of certain murine hybridoma and plasmacytoma cells (Nordan et al. 1986; Van Damme et al. 1987; Van Snick et al. 1986) as well as some human myeloma cells (Kawano et al. 1988) . IL-6 also stimulates activated normal B cells and selected B cell lines to differentiate to immunoglobulin secretion without inducing growth (Hirano et al. 1985; Muraguchi et al. 1988; Raynal et al. 1989).

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Authors and Affiliations

  1. Department of Microbiology and Immunology, UCLA School of Medicine and the Molecular Biology Institute, University of California Los Angeles, 90024, California, USA

    Koichi Nakajima & Randolph Wall

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  1. Koichi Nakajima
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  2. Randolph Wall
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Editors and Affiliations

  1. Laboratory of Genetics, National Institutes of Health, National Cancer Institute, Bethesda, MD, 20892, USA

    Michael Potter M.D.

  2. Basel Institute for Immunology, Grenzacherstraße 487, CH-4005, Basel, Switzerland

    Fritz Melchers

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© 1990 Springer-Verlag Berlin Heidelberg

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Nakajima, K., Wall, R. (1990). IL-6 Induces Hybridoma Cell Growth Through a Novel Signalling Pathway. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1990. Current Topics in Microbiology and Immunology, vol 166. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75889-8_8

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  • DOI: https://doi.org/10.1007/978-3-642-75889-8_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75891-1

  • Online ISBN: 978-3-642-75889-8

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