Relative Predispositional Effect of a PADPRP Marker Allele in B-Cell and Some Non B-Cell Malignancies
The gene PADPRP codes for a nuclear enzyme Poly (ADP-ribose) polymerase. This enzyme is a DNA binding protein that modulates chromatin structure adjacent to DNA strand breaks (Smulson and Sugimura 1980). The polymerase catalyzes the transfer of the ADP-ribose moiety of NAD to a variety of nuclear proteins and to itself, such that a long chain of ADP-ribose units attached to nuclear proteins is formed. The enzyme also functions as one of the major acceptors for poly ADP-ribose. The principal clue to the cellular function of poly (ADP-ribose) polymerase arises from the observation that the catalytic activity of the enzyme is obligately dependant upon the presence of DNA breaks, both in vivo and in vitro. It has hence been implicated in playing a role in DNA repair (Benjamin and Gill 1980), perhaps stabilizing the broken ends of DNA strands.
KeywordsLymphoma Codon Leukemia Recombination Expense
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