Relative Predispositional Effect of a PADPRP Marker Allele in B-Cell and Some Non B-Cell Malignancies

  • Kishor Bhatia
  • Konrad Huppi
  • Barry Cherney
  • Mark Raffeld
  • Mark Smulson
  • Ian Magrath
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 166)

Abstract

The gene PADPRP codes for a nuclear enzyme Poly (ADP-ribose) polymerase. This enzyme is a DNA binding protein that modulates chromatin structure adjacent to DNA strand breaks (Smulson and Sugimura 1980). The polymerase catalyzes the transfer of the ADP-ribose moiety of NAD to a variety of nuclear proteins and to itself, such that a long chain of ADP-ribose units attached to nuclear proteins is formed. The enzyme also functions as one of the major acceptors for poly ADP-ribose. The principal clue to the cellular function of poly (ADP-ribose) polymerase arises from the observation that the catalytic activity of the enzyme is obligately dependant upon the presence of DNA breaks, both in vivo and in vitro. It has hence been implicated in playing a role in DNA repair (Benjamin and Gill 1980), perhaps stabilizing the broken ends of DNA strands.

Keywords

Lymphoma Codon Leukemia Recombination Expense 

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References

  1. Benjamin RC, Gill DM, (1980) J Biol Chem 255:10502–10508PubMedGoogle Scholar
  2. Cherney B, McBride OW, Chen D, Alkhatib M, Bhatia K, Hensley P, Smulson, ME (1987) Proc Natl Acad Sci (USA) 84:8370–8374CrossRefGoogle Scholar
  3. Cory S, Activiation of cellular oncogenes in hemopietic cells by chromosome translocations. Adv Can Res 47: 198–234Google Scholar
  4. Huppi K, Bhatia K, Siwarski D, Klinman D, Cherney B, Smulson M (1989) Sequence and organizations of the mouse poly (ADP-ribose) polymerase. Nucleic Acids Res pp 3387–3401Google Scholar
  5. Mikkelsen T, Cavenee W (1990) Suppressors of the malignant phenotype. Cell Growth and Differentiation 1:201–207PubMedGoogle Scholar
  6. Potter M, Sanford KK, Parshad R, Tarone, RE, Price SM, Mock B, Huppi K (1988) Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation induced chromatin damage. Genomics Vol 2:257–62CrossRefGoogle Scholar
  7. Smulson ME, Sugimura T, eds (1980) Novel ADP-ribosylations of regulatory enzymes and proteins. Elsevier/North Holland, New YorkGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Kishor Bhatia
    • 1
  • Konrad Huppi
    • 1
  • Barry Cherney
    • 1
    • 2
  • Mark Raffeld
    • 1
  • Mark Smulson
    • 1
    • 2
  • Ian Magrath
    • 1
  1. 1.National Institutes of Health, National Cancer InstituteBethesdaUSA
  2. 2.Dept. of Biochemistry and Molecular BiologyGeorgetown UniversityUSA

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