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Epstein-Barr Virus Latency and Activation in Vivo

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Mechanisms in B-Cell Neoplasia 1990

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 166))

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Abstract

Epstein-Barr virus (EBV) infects most human beings in childhood or adolescence. Lifelong latency is established after primary infection.

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References

  • Andersson J, Sköldenberg B, Ernberg I, Britton S, Henle W, Andersson U (1985) Acyclovir treatment in primary Epstein-Barr virus infection. A double blind placebo controlled study Scand J Inf Dis, supplement 47:107–115

    Google Scholar 

  • Anderssson J, Britton S, Ernberg I, Andersson U, Henle W, Sköldenberg B, Tisell A (1986) Effect of acyclovir on infectious mononucleosis. A double-blind, placebo-controlled study J Inf Dis 153:283–290

    Article  Google Scholar 

  • Andersson J, Sköldenberg B, Henle W, Britton S, Ernberg I (1987) Peroral acyclovir treatment in infectious mononucleosis Infection 15:14–21

    Article  Google Scholar 

  • Chang RS (1980) Infectious mononucleosis GK Hall Medical Publishers Boston p 130

    Google Scholar 

  • Ernberg I, Masucci G, Klein G (1976) Persistence of Epstein-Barr virus nuclea antigen (EBNA) in cells entering EB viral cycle Int J Cancer 17:197–203

    Article  Google Scholar 

  • Ernberg I, Andersson J (1986) Acyclovir efficiently inhibits oro-pharyngeal excretion of Epstein-Barr virus in patients with acute infectious mononucleosis J Gen Virol 67:2267–2272

    Article  PubMed  CAS  Google Scholar 

  • Ernberg I, Kallin B, Dillner J, Falk K, Ehlin-Henriksson B, Klein G (1986) Lymphoblastoid cell lines and Burkitt lymphoma derived cell lines differ in the expression of a second Epstein-Barr virus encoded nuclear antigen Int J Cancer 38: 729–737

    Article  PubMed  CAS  Google Scholar 

  • Ernberg I, Danell E, Gratama JW, Oosterveer MAP, Klein, G (1989). Molecular weight variation of EBNAs as a mechanism to identify different Epstein-Barr virus isolates In Epstein-Barr virus and human disease II (Humana Press, Eds Ablashi) 341–347

    Chapter  Google Scholar 

  • Ernberg I (1988) Growth transformation of B lymphocytes by Epstein-Barr virus Cancer Rev 10:92–107

    Google Scholar 

  • Ernberg I, Falk K, Minarovits J, Busson P, Tursz T, Masuc ci MG, Klein G (1989) The role of methylation in the pheno type dependent modulation of EBNA 2 and LMP genes in latently EBV infected cells J Gen Virol 70:2989–3002

    Article  PubMed  CAS  Google Scholar 

  • Falk K, Ernberg I, Sakthivel R, Davis J, Christensson B, Luka J, Grierson H, Klein G, Purtilo D. Expression of Epstein-Barr virus encoded proteins and B-cell antigens in fatal infecttious mononucleosis Subm for publication

    Google Scholar 

  • Farrell PJ, Rowe DT, Rooney CM, Kouzarides T (1989) Epstein-Barr virus BZLF 1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos EMBO J 8:127–132

    PubMed  CAS  Google Scholar 

  • Fåhraeus R, Fu Hu-Li, Ernberg I, Finke J, Rowe M, Klein, G, Falk K, Nilsson E, Yadav M, Busson P, Tursz T, Kallin B (1988) Expression of Epstein-Barr virus encoded proteins in nasopharyngeal carcinoma Int J Cancer 42:329–338

    Article  PubMed  Google Scholar 

  • Gratama JW, Oosterveer MAP, Zwaan FE, Lepoutre J, Klein G, Ernberg I (1988) Eradication of Epstein-Barr virus by allogeneic bone-marrow transplantation: Implications for sites of viral latency Proc Natl Acad Sci 85:8693–8696

    Article  PubMed  CAS  Google Scholar 

  • Gratama JW, Oosterveer MAP, Lepoutre J, van Rood JJ, Zwaan FE, Vossen JMJJ, Kapsenberg JG, Klein G, Ernberg I (1989) Persistence and transfer of Epstein-Barr virus after allo geneic bone marrow transplantation Transplantation Proceedings 21:3097–3098

    PubMed  CAS  Google Scholar 

  • Gratama J, Zutter MM, Minarovits J, Oosterveer MAP, Thomas ED, Klein G, Ernberg I. Expression of Epstein- Barr virus growth transformation-associated proteins in lymphoprolierative lesions of bone marrow transplant recipients Subm for publication

    Google Scholar 

  • Greenspan JS, Greenspan D, Lennette ET, Abrahams DJ, Conant MA, Petersen V, Freese UK (1985) Replication of Esptein-Barr virus within the epothelial cells of oral “hairy” leukoplakia, an AIDS-associated lesion N Engl J Med 313:1564–1571

    Article  PubMed  CAS  Google Scholar 

  • Honess RW, Gompels UA, Barrell BG, Craxton M, Cameron KR, Staden R, Chang YN, Hayward GS (1989) Deviation from expected frequencies of CpG dinucleotides in herpesvirus DNAs may be diagnostic of differences in the states of their latent genomes J Gen Virol 70:837–855

    Article  PubMed  CAS  Google Scholar 

  • Klein G, Giovanella BC, Lindahl T, Fialkow PJ, Singh S, Stehlin J (1974) Direct evidence for the presence of Epstein-Barr virus DNA and nuclear antigen in malignant epithelial cells from patients with anaplastic carcinoma of the nasopharynx Proc Natl Acad Sci 71:4737–4741.

    Article  PubMed  CAS  Google Scholar 

  • Klein G, Svedmyr E, Jondal M, Persson PO (1976) EBV-determined nuclear antigen (EBNA) positive cells in the peripheral blood of infectious mononucleosis patients Int J Cancer 17:21–26

    Article  PubMed  CAS  Google Scholar 

  • Klein G (1989) Viral latency and transformation: the strategy of Epstein-Barr virus Cell 58:5–8

    Article  PubMed  CAS  Google Scholar 

  • Li-Fu H, Minarovits J, Shi-Long C, Contreras-Salazar B, Rymo L, Falk K, Klein G, and Ernberg I.Hypomethylation of BNLF 1 5′-flanking region corelates to EBV-LMP (latent membrane protein) expression in nasopharyngeal carcinoma Subm for publication

    Google Scholar 

  • Lewin N, Aman P, Masucci MG, Klein E, Klein G, öberg B, Strander H, Henle W, Henle G (1987) Characterization of EBV-carrying B-cell populations in healthy seropositive individuals with regard to density, release of transforming virus and spontaneous outgrowth Int J Cancer 39:472–476

    Article  PubMed  CAS  Google Scholar 

  • Masucci MG, Contreras-Salazar B, Ragnar, E, Falk K, Minarovits J, Ernberg I, Klein G.(1989) 5-azacytidine up- regulates the expression of EBNA 2–6 and LMP in EBNA 1 positive, EBNA 2–6 and LMP-negative Burkitt lymphoma line J Virol 63: 3135–3141

    PubMed  CAS  Google Scholar 

  • Minarovits J, Klein G, Ernberg I (subm for publication) EBV DNA methylation in Burkitt lymphoma tumor biopsies and derived cell lines

    Google Scholar 

  • Nilsson K (1971) High frequency-establishment of human immunoglo-bulin producing lymphoblastoid cell lines from normal and malignant tissue and peripheral blood Int J Cancer 8:432–42

    PubMed  CAS  Google Scholar 

  • Nilsson K Klein G, Henle W, Henle G (1971) The establishment of lymphoblastoid lines from adult and fetal human lymphoid tissue and its dependence on EBV Int J Cancer 8:443–450

    PubMed  CAS  Google Scholar 

  • Ragona G, Sirianni M, Soddu S, Vercelli B, Piccoli M, Aiuti F (1986) Evidence for disregulation in the control of Epstein-Barr virus latency in patients with AIDS-related complex Clin Exp Immunol 66:17–24

    PubMed  CAS  Google Scholar 

  • Rinaldo C, Kingsley L, Lyter DW, Rabin B, Atchison RW, Bodner AJ, Weiss SH, Saxinger WC (1986) Association of HTLV III with Epstein-Barr virus infection and abnormalities of T lymphocytes in homosexual men J Infect Dis 154:556–561

    Article  PubMed  Google Scholar 

  • Rickinson AB (1986) Cellular immunological responses to the virus infection. In “The Epstein-Barr virus” (Eds Esptein and Achong) William Heineman Med Books, London, p 75

    Google Scholar 

  • Robinson J, Smith D, Niederman J (1980) Mitotic EBNA positive lymphocytes in peripheral blood during infectious mononucleosis Nature 287:234–235

    Google Scholar 

  • Rowe DT, Rowe M, Evan G, Wallace LE, Farrel PJ, Rickinson AB (1986) Restricted expression of EBV latent genes and T lymphocyte detected membrane antigen in Burkitt’s lymphoma cells EMBO J 5:2599–2607

    PubMed  CAS  Google Scholar 

  • Rowe M, Gregory C (1989) Epstein-Barr virus and Burkitt’s lymphoma In “Adv in Viral Oncology” (Ed G Klein), Raven Press, New York 8:237–259

    Google Scholar 

  • Sakthivel R, Christensson B, Ehlin-Henriksson B, Klein G (1989) Immunophenotypic characterization of follicle-center-cell-derived non-Hodgkin’s lymphomas Int J Cancer 43:624–630

    Article  PubMed  CAS  Google Scholar 

  • Sixbey JW, Veserinen EH, Nedryd JG, Raab-Traub N, walton LA, Pagano JS (1983) Replication of Epstein-Barr virus in human epithelial cells infected in vitro Nature 306:480–483

    Article  PubMed  CAS  Google Scholar 

  • Svedmyr ES, Ernberg I, Seeley J, Weiland O, Masucci G, Tsukuda K, Szigeti R, Masucci MG, Blomgren H, Berthold W, Henle W, Klein G (1984) Virologic, immunologic and clinical observations on a patient during the incubation, acute and convalescent phases of infectious mononucleosis Clin Immunol Immunopathol 30:437–450.

    Article  PubMed  CAS  Google Scholar 

  • Yao QY, Rickinson AB, Epstein MA (1985) A re-examination of the EBV-virus carrier state in healthy seropositive individuals Int J Cancer 35:35–42

    Article  PubMed  CAS  Google Scholar 

  • Yao QY, Ogan P, Rowe M, Wood M, Rickinson AB (1989) Epstem-Barr virus-infected B cells persist in the circulation of acyclovir treated carriers Int J Cancer 43:67–71

    Article  PubMed  CAS  Google Scholar 

  • Young L, Alfieri C, Hennessy K, Evans H, O’Hara C, Andersson KC, Ritz J, Shapiro RS, Rickinson AB, Kieff E, Cohen JI (1989) Expression of Epstein-Barr virus transformation associated genes in tisuues of patients with EBV lymphoproliferative disease N Eng J Med 321:1080–1085

    Article  CAS  Google Scholar 

  • zur Hausen H; Schulte-Holthausen H, Klein G, Henle W, Henle G, Clifford P, Santesson L (1970) EBV DNA in biopsies of Burkitts tumours and anaplastic carcinomas of the nasopahrynx Nature 228:1056–1058

    Article  PubMed  CAS  Google Scholar 

  • Zutter MM, Martin PJ, Sale GE et al.(1988) Epstein-Barr virus lymphoproliferation after bone marrow transplantation Blood 72:520–529

    PubMed  CAS  Google Scholar 

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© 1990 Springer-Verlag Berlin Heidelberg

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Ernberg, I. (1990). Epstein-Barr Virus Latency and Activation in Vivo. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1990. Current Topics in Microbiology and Immunology, vol 166. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75889-8_42

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  • DOI: https://doi.org/10.1007/978-3-642-75889-8_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75891-1

  • Online ISBN: 978-3-642-75889-8

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