Abstract
We have studied DNA repair after UV damage in the murine c-mvc locus. It appears that a region in B cells upstream of the murine c-myc gene is repaired with a different efficiency in plasmacytoma-resistant DBA/2N mice than in plasmacytoma-susceptible BALB/cAn mice. The region just uptream of c-myc is inefficiently repaired in B lymphoblasts derived from BALB/cAn mice. In contrast, this same region of c-mvc is efficiently repaired in B lymphoblasts derived from DBA/2N mice. DNA fragments located in the coding region of c-myc and in another gene, dihydrofolate reductase (DHFR), are repaired with equal efficiency in cells from these two strains of mice. It is possible that repair efficiency of the 5′ flank of c-mvc may be involved in tumor susceptibility of the mouse strain.
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© 1990 Springer-Verlag Berlin Heidelberg
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Beecham, E.J., Mushinski, J.F., Shacter, E., Potter, M., Bohr, V.A. (1990). DNA Repair in the c-myc Locus. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1990. Current Topics in Microbiology and Immunology, vol 166. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75889-8_35
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DOI: https://doi.org/10.1007/978-3-642-75889-8_35
Publisher Name: Springer, Berlin, Heidelberg
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