Recombination of the c-myc Gene with IgH Enhancer-Sμ Sequences in a Murine Plasmacytoma (DCPC 21) Without Visible Chromosomal Translocations

  • S. Ohno
  • S. Migita
  • S. Murakami
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 166)


Murine plasmacytomas (MPCs) consistently exhibit chromosomal translocations involving chromosome 15 (t(12;15) or t(6;15)) (Ohno et al. 1979, 1984, 1988). These translocations of chromosomes juxtapose the proto-oncogene c-myc to the one of Ig gene loci (Cory 1986) . The juxtaposition of c-myc and the Ig gene strongly suggests that they play a critical genomic role in the development of MPCs probably by deregulating the c-myc gene expression.


Chromosomal Translocation Recombination Site Diffusion Chamber SacI Fragment Heavy Chain Class Switching 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • S. Ohno
    • 1
  • S. Migita
    • 1
  • S. Murakami
    • 2
  1. 1.Department of Molecular Immunology, Cancer Research InstituteKanazawa UniversityKanazawaJapan
  2. 2.Division of Biophysics, Cancer Research InstituteKanazawa UniversityKanazawaJapan

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