Recombination of the c-myc Gene with IgH Enhancer-Sμ Sequences in a Murine Plasmacytoma (DCPC 21) Without Visible Chromosomal Translocations
Murine plasmacytomas (MPCs) consistently exhibit chromosomal translocations involving chromosome 15 (t(12;15) or t(6;15)) (Ohno et al. 1979, 1984, 1988). These translocations of chromosomes juxtapose the proto-oncogene c-myc to the one of Ig gene loci (Cory 1986) . The juxtaposition of c-myc and the Ig gene strongly suggests that they play a critical genomic role in the development of MPCs probably by deregulating the c-myc gene expression.
KeywordsChromosomal Translocation Recombination Site Diffusion Chamber SacI Fragment Heavy Chain Class Switching
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