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Expression of c-myc and Pvt1

  • J. F. Mushinski
  • R. M. SkurlaJr.
  • J. Goodnight
  • D. Siwarski
  • K. Huppi
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 166)

Abstract

Deregulated expression of c-myc secondary to chromosomal alterations is a constant feature of mouse plasmacytomas, rat immunocytomas and human Burkitt lymphomas (Mushinski, 1988). One feature of deregulated expression of c-myc is that all plasmacytomas have high levels of c-myc transcripts, no matter whether their chromosome 15 was interrupted by a rcpt(12;15) translocation, by a rcpt(6;15) translocation, or by interstitial deletion within chromosome 15.

Keywords

Normal Thymus Deregulate Expression Human Burkitt Lymphoma Murine Plasmacytoma Light Chain Versus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • J. F. Mushinski
    • 1
  • R. M. SkurlaJr.
    • 1
  • J. Goodnight
    • 1
  • D. Siwarski
    • 1
  • K. Huppi
    • 1
  1. 1.Laboratory of GeneticsNational Cancer InstituteBethesdaUSA

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