Expression of c-myc and Pvt1

  • J. F. Mushinski
  • R. M. SkurlaJr.
  • J. Goodnight
  • D. Siwarski
  • K. Huppi
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 166)

Abstract

Deregulated expression of c-myc secondary to chromosomal alterations is a constant feature of mouse plasmacytomas, rat immunocytomas and human Burkitt lymphomas (Mushinski, 1988). One feature of deregulated expression of c-myc is that all plasmacytomas have high levels of c-myc transcripts, no matter whether their chromosome 15 was interrupted by a rcpt(12;15) translocation, by a rcpt(6;15) translocation, or by interstitial deletion within chromosome 15.

Keywords

Lymphoma Recombination Electrophoresis Nylon Plasmacytomas 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cory S Graham M, Webb E, Corcoran L, Adams JM (1985) Variant (6:15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene. EMBO J 4: 675–681PubMedGoogle Scholar
  2. Graninger WB, Seta M, Bautain B, Goldman P, Korsmeyer S (1987) Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells. J Clin Invest 80: 1512–1515PubMedCrossRefGoogle Scholar
  3. Gurfinkel N Unger T, Givol D, Mushinski JF (1987) Expression of the bcl-2 gene in mouse B lymphocytic cell lines is differentiation stage specific. Eur J Immunol 17: 567–570PubMedCrossRefGoogle Scholar
  4. Henglein B, Synovzil H, Groitl P, Bornkamm GW, Hartl P, Lipp M (1989) Three breakpoints of variant t(2;8) translocations in Burkit’s lymphoma cells fall within a region 140 kilobases distal from c-myc. Mol Cell Bio 9: 2105–2113Google Scholar
  5. Huppi K Siwarski D, Skurla RMJr, Mushinski JF (1990) Isolation of normal and tumor-specific Pvt-1 cDNA clones. Curr Top Micro Immunol (this volume)Google Scholar
  6. Graham M, Adams JM (1986) Chromosome 8 breakpoint far 3′ of the c-myc oncogene in a Burkit’s lymphoma 2;8 variant translocation is equivalent to the murine PVT-1 locus. EMBO J 5: 2845–2851PubMedGoogle Scholar
  7. Mushinski JF, Davidson WF, Morse HC III (1987) Activations of cellular oncogenes in human and mouse leukemia-lymphomas: spontaneous and induced oncogene expression in murine B lymphocytic neoplasms. Cancer Invest 5: 345–368PubMedGoogle Scholar
  8. Mushinski JF (1988) c-myc oncogene activation and chromosomal translocations in BALB/c plasmacytomas. in Cellular Oncogene Activation, Klein G (ed) Pp. 181–222 Marcel Dekker, Inc., New YorkGoogle Scholar
  9. Shtivelman E Bishop JM (1989) The PVT gene frequently amplifies with MYC in tumor cells. Mol Cell Biol 9: 1148–1154PubMedGoogle Scholar
  10. Shtivelman E et al. (1989) Identification of human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphomas. Proc Nat Acad Sci (USA) 86: 3257–3261CrossRefGoogle Scholar
  11. Shtivelman E Bishop JM (1990) Effects of Translocations on Transcription from PVT. Mol Cell Biol 10: 1835–1839PubMedGoogle Scholar
  12. Stanton, LW, Watt R, Marcu KB (1983) Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas. Nature 303: 401– 406PubMedCrossRefGoogle Scholar
  13. Tsujimoto Y, Cossman J, Jaffe E, Croce CM (1985) Involvement of the bcl-2 gene in human follicular lymphoma. Science 228: 1440–1443PubMedCrossRefGoogle Scholar
  14. Webb E, Adams JM, Cory S (1984) Variant (6;15) translocation in a murine plasmacytoma occurs near an immunoglobulin κ gene but far from the myc oncogene. Nature 312: 777–779PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • J. F. Mushinski
    • 1
  • R. M. SkurlaJr.
    • 1
  • J. Goodnight
    • 1
  • D. Siwarski
    • 1
  • K. Huppi
    • 1
  1. 1.Laboratory of GeneticsNational Cancer InstituteBethesdaUSA

Personalised recommendations