Expression of c-myc and Pvt1
Deregulated expression of c-myc secondary to chromosomal alterations is a constant feature of mouse plasmacytomas, rat immunocytomas and human Burkitt lymphomas (Mushinski, 1988). One feature of deregulated expression of c-myc is that all plasmacytomas have high levels of c-myc transcripts, no matter whether their chromosome 15 was interrupted by a rcpt(12;15) translocation, by a rcpt(6;15) translocation, or by interstitial deletion within chromosome 15.
KeywordsLymphoma Recombination Electrophoresis Nylon Plasmacytomas
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