The Human CBL Oncogene

  • W. Y. Langdon
  • T. J. Blake
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 166)


The v-cbl oncogene was identified as the transforming gene of the murine Cas NS-1 retrovirus (Langdon et al. 1989a), This novel viral oncogene transforms fibroblasts in vitro and induces pre-B, pro-B and myeloid tumors in vivo. Probes prepared from v-cbl have identified its cellular homolog (c-cbl) in mouse, rat and human DNA, and it is expressed as an 11 kb mRNA in a range of murine and human hemopoietic tumor cell lines. In normal cells highest levels of c-cbl mRNA are found in the testis and thymus (Langdon et al. 1989b). The c-cbl product is a 135 kD protein which is localized in the nucleus, as in the 100 kD gag-cbl fusion protein (Langdon et al. 1989b).


Myeloid Tumor Cellular Homolog Hormone Responsive Gene Negative Growth Regulation Amino Aeid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bohmann, D and Tjian R (1989) Biochemical analysis of transcriptional activation by jun. Differential activation of c-and v-jun. Cell 59, 709–717PubMedCrossRefGoogle Scholar
  2. Damm, K, Thompson CC and Evans RM (1989). Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. Nature 339, 593–597PubMedCrossRefGoogle Scholar
  3. Foley, GE, Lazarus H, Farber S, uzman, BG, Boone, BA and McCarthy, RE (1965) Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia. Cancer 18, 522–529PubMedCrossRefGoogle Scholar
  4. Gazdar, AF, Carney, DN, Bun, PA, Russell, EK, Jaffe, ES, Schechter, GP, and Guccion, JG (1980) Mitogen requirements for the In vitro propagation of cutaneous T-cell lymphomas Blood 55, 409–417PubMedGoogle Scholar
  5. Langdon, WY, Hartley, JW, Klinken, SP, Ruscetti, SK and Morse, HC III (1989a). v-cbl an oncogene from a dual-recombinant retrovirus that induces early B-lineage lymphomas. Proc. Natl. Acad. Sci. USA 86 1168–1172PubMedCrossRefGoogle Scholar
  6. Langdon, WY, Hyland, CD, Grumont, RJ and Morse, HC III (1989b) The c-cbl proto-oncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein J. Virol. 63, 5420–5424PubMedGoogle Scholar
  7. Mermod, N, O’Neill, EA, Kelly, TJ and Tjian, R (1989) The proline-rich transcriptional activator of CTF/NF-1 is distinct from the replication and DNA binding domain. Cell 58, 741–753PubMedCrossRefGoogle Scholar
  8. Regnier, DC, Kozak, CA, Kingsley DM, Jenkins, NA, Copeland, NG, Langdon, WY and Morse, HC III (1989). Identification of two murine loci homologous to the v-cbl oncogene. J. Virol.63, 3678–3682PubMedGoogle Scholar
  9. Yunis, JJ and Brunning, RD (1986) Prognostic significance of chromosomal abnormalities in acute leukemias and myelodysplastic syndromes. Clin. Haematol. 15, 597–619.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • W. Y. Langdon
    • 1
  • T. J. Blake
    • 1
  1. 1.Division of Human ImmunologyInstitute of Medical and Veterinary ScienceAdelaideAustralia

Personalised recommendations