Abstract
The v-cbl oncogene was identified as the transforming gene of the murine Cas NS-1 retrovirus (Langdon et al. 1989a), This novel viral oncogene transforms fibroblasts in vitro and induces pre-B, pro-B and myeloid tumors in vivo. Probes prepared from v-cbl have identified its cellular homolog (c-cbl) in mouse, rat and human DNA, and it is expressed as an 11 kb mRNA in a range of murine and human hemopoietic tumor cell lines. In normal cells highest levels of c-cbl mRNA are found in the testis and thymus (Langdon et al. 1989b). The c-cbl product is a 135 kD protein which is localized in the nucleus, as in the 100 kD gag-cbl fusion protein (Langdon et al. 1989b).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bohmann, D and Tjian R (1989) Biochemical analysis of transcriptional activation by jun. Differential activation of c-and v-jun. Cell 59, 709–717
Damm, K, Thompson CC and Evans RM (1989). Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. Nature 339, 593–597
Foley, GE, Lazarus H, Farber S, uzman, BG, Boone, BA and McCarthy, RE (1965) Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia. Cancer 18, 522–529
Gazdar, AF, Carney, DN, Bun, PA, Russell, EK, Jaffe, ES, Schechter, GP, and Guccion, JG (1980) Mitogen requirements for the In vitro propagation of cutaneous T-cell lymphomas Blood 55, 409–417
Langdon, WY, Hartley, JW, Klinken, SP, Ruscetti, SK and Morse, HC III (1989a). v-cbl an oncogene from a dual-recombinant retrovirus that induces early B-lineage lymphomas. Proc. Natl. Acad. Sci. USA 86 1168–1172
Langdon, WY, Hyland, CD, Grumont, RJ and Morse, HC III (1989b) The c-cbl proto-oncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein J. Virol. 63, 5420–5424
Mermod, N, O’Neill, EA, Kelly, TJ and Tjian, R (1989) The proline-rich transcriptional activator of CTF/NF-1 is distinct from the replication and DNA binding domain. Cell 58, 741–753
Regnier, DC, Kozak, CA, Kingsley DM, Jenkins, NA, Copeland, NG, Langdon, WY and Morse, HC III (1989). Identification of two murine loci homologous to the v-cbl oncogene. J. Virol.63, 3678–3682
Yunis, JJ and Brunning, RD (1986) Prognostic significance of chromosomal abnormalities in acute leukemias and myelodysplastic syndromes. Clin. Haematol. 15, 597–619.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Langdon, W.Y., Blake, T.J. (1990). The Human CBL Oncogene. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1990. Current Topics in Microbiology and Immunology, vol 166. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75889-8_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-75889-8_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-75891-1
Online ISBN: 978-3-642-75889-8
eBook Packages: Springer Book Archive