Interleukin 6 (IL-6) and Its Receptor (IL-6R) in Myeloma/Plasmacytoma
Interleukin 6 (IL-6) was originally identified as a B cell differentiation factor (BCDF/BSF2) which induces final maturation of B cells into antibody producing cells (Hirano et al 1986). However, subsequent studies with recombinant molecules revealed that IL-6 has a wide variety of biological functions on various tissues and cells (Kishimoto 1989). As shown in Fig. 1, IL-6 acts not only on B cells but also on hematopoietic progenitors and hepatocytes and is involved in hematopoiesis and acute phase reactions. It also acts on nerve cells, epidermal keratinocytes and kidney mesangium cells. One of the most interesting activities is the induction of the growth of myeloma/plasmacytoma cells. IL-6 is a potent growth factor for myelomas/plasmacytomas and only 0.002 ng/ml of rIL-6 could induce 50% of the maximum proliferation in a human myeloma cell line (Muraguchi et al 1988). This concentration of IL-6 is 100-fold less than that required for the immunoglobulin induction in B cells.
KeywordsMyeloma Cell Extracellular Portion Human Multiple Myeloma Human Myeloma Cell Line Potent Growth Factor
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