Abstract
Raf-1 is a cytosolic serine/threonine-specific protein kinase that is ubiquitously expressed (Storm et al., 1990). The raf-1 gene can be converted into an oncogene by N-terminal fusion, truncation, or by site-specific mutation (Heidecker et al., 1990). When activated forms of the raf-1 gene were expressed in E. coli, the purified protein had kinase activity in vitro and induced DNA synthesis as well as morphological transformation upon microinjection into quiescent NIH 3T3 cells (Smith et al., 1990). Thus, activated raf-1 is an intracellular mitogen.
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Rapp, U.R., Troppmair, J., Carroll, M., May, S. (1990). Role of raf-1 Protein Kinase in IL-3 and GM-CSF-Mediated Signal Transduction. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1990. Current Topics in Microbiology and Immunology, vol 166. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75889-8_17
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DOI: https://doi.org/10.1007/978-3-642-75889-8_17
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