Abstract
The role of immunoglobulin-binding factors (IBF) in the isotype-specific regulation of immunoglobulin production has been the subject of many studies (reviewed by Fridman 1987 ). A variety of soluble factors, that bind all classes of immunoglobulins in an isotype-specific manner, have been described and can augment or suppress B cell growth and differentiation in an isotype-specific fashion (Fridman 1987). Evidence has been presented that certain IBF have homology at the protein level with cell surface Fc receptors (Huff 1984; Peterson 1985). Thus, at least for some IBF, it is likely that the factor is a secreted or shed portion of the cell surface Fc receptor. IgA-binding factors, produced by cloned lines of T cells, that bear surface IgA-Fc receptors, or by T cell blasts induced with IgA, have been described and depending upon the circumstances, can mediate either IgA-specific help or suppression (Adachi 1984; Kiyono 1985; Yodoi 1983).
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Hoover, R.G., Roman, S., Moore, J.S., Darby, C., Müller, S. (1990). Modulation of Growth and Differentiation of Murine Myeloma Cells by Immunoglobulin Binding Factors. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1990. Current Topics in Microbiology and Immunology, vol 166. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75889-8_11
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