Abstract
The growth and differentiation of normal B-cells are under stringent control by complex cell-cell interactions, including cell-cell contacts and growth-and differentiation factor signalling. The activation of resting B-cells, and their subsequent growth and/or differentiation, have thus been found to be regulated by multiple, alternative cytokines acting in concert to ensure a fine-tuned control of the process. Malignant B-cells, best exemplified by chronic lymphocytic leukemia cells, have also been found to require such complex signalling for activation-, growth- and differentiation induction. (Nilsson 1989). It was therefore surprising when Kawano et al (1988) reported that the growth of human multiple myeloma (MM) biopsy cells in vitro could be stimulated by IL-6 and serum only, and that the growth could be inhibited by anti-IL-6 antibodies.
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© 1990 Springer-Verlag Berlin Heidelberg
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Nilsson, K., Jernberg, H., Pettersson, M. (1990). IL-6 as a Growth Factor for Human Multiple Myeloma Cells - A Short Overview. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1990. Current Topics in Microbiology and Immunology, vol 166. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75889-8_1
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