A Challenge to Osteointegrable Tumor Prosthesis
Rigid fixation of prosthesis is almost impossible to attain in limbs which have been subjected to limb saving surgery for osteosarcoma. The reasons for this may be the limited length of the remaining segment after wide resection, fragility, and reduced reparative capacity of bone after chemotherapy or radiation. We thought that enhancing the reparative capacity of the bone by using osteointegrable tumor prosthesis could be a solution to this problem. We surmised that once the prosthesis was encased within newly formed bone mass expanding on the surface of the prosthesis or bridging both ends of the limb bone, a satisfactory rigid fixation of the prosthesis (osteointegration of the prosthesis) could be obtained. For this purpose we need to apply new technology and some bioactive factors that promote local bone formation. Bone morphogenetic protein (BMP) [I] is one such factor. Its advantages are unmatched due to the fact that it can be utilized in combination with tumor prosthesis.
KeywordsBone Formation Bone Morphogenetic Protein Bone Defect Periosteal Bone Formation Tumor Prosthesis
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