Advertisement

Limb Salvage pp 311-317 | Cite as

A Challenge to Osteointegrable Tumor Prosthesis

  • K. Takaoka
  • S. Miyamoto
  • H. Yoshikawa
  • K. Ono
Conference paper

Abstract

Rigid fixation of prosthesis is almost impossible to attain in limbs which have been subjected to limb saving surgery for osteosarcoma. The reasons for this may be the limited length of the remaining segment after wide resection, fragility, and reduced reparative capacity of bone after chemotherapy or radiation. We thought that enhancing the reparative capacity of the bone by using osteointegrable tumor prosthesis could be a solution to this problem. We surmised that once the prosthesis was encased within newly formed bone mass expanding on the surface of the prosthesis or bridging both ends of the limb bone, a satisfactory rigid fixation of the prosthesis (osteointegration of the prosthesis) could be obtained. For this purpose we need to apply new technology and some bioactive factors that promote local bone formation. Bone morphogenetic protein (BMP) [I] is one such factor. Its advantages are unmatched due to the fact that it can be utilized in combination with tumor prosthesis.

Keywords

Bone Formation Bone Morphogenetic Protein Bone Defect Periosteal Bone Formation Tumor Prosthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Urist MR (1965) Bone formation by autoinduction. Science 150: 893PubMedCrossRefGoogle Scholar
  2. 2.
    Takaoka K, Yoshikawa H, Shimizu N, Ono K, Amitani K, Nakata Y (1982) Partial purification of bone-inducing substances from a murine osteosarcoma. Clin Orthop 164: 265PubMedGoogle Scholar
  3. 3.
    Urist MR, Delange RI, Fimerman GAM (1983) Bone cell differentiation and growth factors. Science 220: 680PubMedCrossRefGoogle Scholar
  4. 4.
    Kawamura M, Urist MR (1988) Induction of callus formation by implants of bone morphogenetic protein and associated bone matrix non-collagenous proteins. Clin Orthop 236: 240PubMedGoogle Scholar
  5. 5.
    Nakahara H, Takaoka K, Koezuka M, Sugamoto K, Tsuda T, Ono K (1989) Periosteal bone formation elicited by partially purified bone morphogenetic protein. Clin Orthop 239: 299PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • K. Takaoka
    • 1
  • S. Miyamoto
    • 1
  • H. Yoshikawa
    • 1
  • K. Ono
    • 1
  1. 1.Department of Orthopaedic SurgeryOsaka University Medical SchoolOsakaJapan

Personalised recommendations