Segmental Allograft Reconstruction Concomitant with Neoadjuvant Chemotherapy
The effect of chemotherapy on the outcome of allograft reconstruction procedures after the resection of bone tumors is of considerable interest in the light of both experimental [1,2] and clinical evidence [3,4] suggesting that it has an adverse effect on bone repair. The crucial clinical issue, however, is whether the failure of allograft reconstruction due to infection, fracture, or both , is especially frequent when performed concomitant with administration of chemotherapy. We addressed this question by evaluating the clinical results and complications of segmental allograft replacement in a group of young patients who were followed prospectively and of whom the majority had high grade sarcomas and were treated with neoadjuvant chemotherapy protocols.
KeywordsCisplatinum Sarcoma Doxorubicin Methotrexate Cyclophosphamide
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