Limb Salvage pp 769-773 | Cite as

Magnetic Resonance Imaging in Evaluating In Vivo Response to Neoadjuvant Chemotherapy for Osteogenic Sarcomas

  • H. J. Hoekstra
  • H. Schraffordt Koops
  • W. R. Hogeboom
  • E. L. Mooyart
  • R. P. H. Veth
  • A. Postma
  • J. W. Oosterhuis
  • J. Oldhoff
Conference paper

Abstract

Conventional X-rays, CT scans, bone scans, and even angiography have been used in the evaluation of the response to neoadjuvant chemotherapy in osteosarcomas. The response to neoadjuvant chemotherapy, however, is best evaluated on the basis of the histologic reaction of the tumor to chemotherapy, as described by Huvos [1]. As magnetic resonance imaging (MRI) has been demonstrated to be of value in diagnosis and superior to conventional CT in assessing resectability in limb-saving treatment of bone tumors [2, 3], the value of MRI in evaluating the in vivo response to neoadjuvant chemotherapy of osteosarcoma was prospectively investigated.

Keywords

Toxicity Sarcoma Methotrexate Lime Cyclophosphamide 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Rosen G, Marcove RC, Caparros B, Nirenberg A, Kossloff C, Huvos AG (1979) Primary osteogenic sarcoma. The rationale for preoperative chemotherapy and delayed surgery. Caner 43: 2163–2177CrossRefGoogle Scholar
  2. 2.
    Sundaram M, McGuire M, Herbold DR, Wolverson MK, Heiberg E (1986) Magnetic resonance imaging in planning limb-salvage surgery for primary malignant tumors of bone. J Bone Joint Surg [Am] 68: 809–819Google Scholar
  3. 3.
    Bloem JL, Taminiau AHM, Eulderik F, Hermans J, Pauwels EKJ (1988) Radiological staging of primary bone sarcoma: MR imaging, scintigraphy, angiography, and CT correlated with pathologic examination. Radiology 169: 805–810PubMedGoogle Scholar
  4. 4.
    Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop 153: 106–120PubMedGoogle Scholar
  5. 5.
    Rosen G, Caparros B, Huvos AG et al. (1982) Preoperative chemotherapy for osteosarcoma. Selection of postoperative adjuvant chemotherapy based on response of the primary tumor to reoperative chemotherapy. Cancer 49: 1221–1230PubMedCrossRefGoogle Scholar
  6. 6.
    Just M, Gutjahr P, Higer HP et al. (1987) Möglichkeiten der MR-Tomographie in der Therapiekontrolle maligner Knochentumoren. Fortschr Geb Röntgenstr 147: 413–419CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • H. J. Hoekstra
    • 1
  • H. Schraffordt Koops
    • 1
  • W. R. Hogeboom
    • 1
  • E. L. Mooyart
    • 2
  • R. P. H. Veth
    • 3
  • A. Postma
    • 4
  • J. W. Oosterhuis
    • 5
  • J. Oldhoff
    • 1
  1. 1.Departments of Surgical OncologyUniversity Hospital GroningenGroningenThe Netherlands
  2. 2.Magnetic ResonanceUniversity Hospital GroningenGroningenThe Netherlands
  3. 3.Orthopaedic SurgeryUniversity Hospital GroningenGroningenThe Netherlands
  4. 4.Pediatric OncologyUniversity Hospital GroningenGroningenThe Netherlands
  5. 5.PathologyUniversity Hospital GroningenGroningenThe Netherlands

Personalised recommendations