Magnetic Resonance Imaging in Evaluating In Vivo Response to Neoadjuvant Chemotherapy for Osteogenic Sarcomas
Conventional X-rays, CT scans, bone scans, and even angiography have been used in the evaluation of the response to neoadjuvant chemotherapy in osteosarcomas. The response to neoadjuvant chemotherapy, however, is best evaluated on the basis of the histologic reaction of the tumor to chemotherapy, as described by Huvos . As magnetic resonance imaging (MRI) has been demonstrated to be of value in diagnosis and superior to conventional CT in assessing resectability in limb-saving treatment of bone tumors [2, 3], the value of MRI in evaluating the in vivo response to neoadjuvant chemotherapy of osteosarcoma was prospectively investigated.
KeywordsToxicity Sarcoma Methotrexate Lime Cyclophosphamide
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- 2.Sundaram M, McGuire M, Herbold DR, Wolverson MK, Heiberg E (1986) Magnetic resonance imaging in planning limb-salvage surgery for primary malignant tumors of bone. J Bone Joint Surg [Am] 68: 809–819Google Scholar