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The Biochemical Events Involved in the Contractile and Positive Inotropic Activity of Endothelin-1

  • Winifred G. Nayler

Abstract

The previous chapter concluded with the statement that “the contractile effect of endothelin-1 is accompanied by a raised cytosolic Ca 2+ . Whilst it is a truism to say that it is the raised cytosolic Ca2+ (Figure 6.1) which is directly responsible for the contractile and positive inotropy of this polypeptide the cascade of events which culminates in this increase are complex.

Keywords

Vascular Smooth Muscle Vascular Smooth Muscle Cell Sarcoplasmic Reticulum Calcium Antagonist Spontaneous Contraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Winifred G. Nayler
    • 1
  1. 1.Department of Medicine Austin and Repatriation HospitalThe University of MelbourneHeidelbergAustralia

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