The Biochemical Events Involved in the Contractile and Positive Inotropic Activity of Endothelin-1

  • Winifred G. Nayler


The previous chapter concluded with the statement that “the contractile effect of endothelin-1 is accompanied by a raised cytosolic Ca 2+ . Whilst it is a truism to say that it is the raised cytosolic Ca2+ (Figure 6.1) which is directly responsible for the contractile and positive inotropy of this polypeptide the cascade of events which culminates in this increase are complex.


Hydrolysis Polypeptide Angiotensin Caffeine Cytosol 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Winifred G. Nayler
    • 1
  1. 1.Department of Medicine Austin and Repatriation HospitalThe University of MelbourneHeidelbergAustralia

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