Kidney Regulation of Erythropoietin Production

  • J. W. Fisher
  • J. Nakashima
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 101)


Hypoxia is the fundamental stimulus for erythropoietin (Ep) production (Fisher 1983, 1988; Kurz et al. 1986). Our model for kidney Ep production postulates that an oxygen deficit initiates a cascade of events which lead to increased biosynthesis and secretion of Ep. The physiologic and pathophysiologic control involved is still not clearly understood. However, there is a primary oxygen-sensing reaction in the kidney which is triggered by a reduction in ambient partial pressure of oxygen (high altitude, hypobaria); a decreased passage of oxygen across the pulmonary endothelium (obstructive lung disease); a decrease in the oxygen-carrying capacity of hemoglobin (anemia); a decrease in oxygen utilization by the kidney (cobalt) (Fisher and Birdwell 1961); and a decrease in the flow of blood to the kidney (renal artery constriction, atherosclerosis, thrombosis).


HepG2 Cell Adenylate Cyclase Cholera Toxin Hep3B Cell Ischemic Hypoxia 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • J. W. Fisher
  • J. Nakashima

There are no affiliations available

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