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Kidney Regulation of Erythropoietin Production

  • Chapter
Biochemical Pharmacology of Blood and Bloodforming Organs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 101))

Abstract

Hypoxia is the fundamental stimulus for erythropoietin (Ep) production (Fisher 1983, 1988; Kurz et al. 1986). Our model for kidney Ep production postulates that an oxygen deficit initiates a cascade of events which lead to increased biosynthesis and secretion of Ep. The physiologic and pathophysiologic control involved is still not clearly understood. However, there is a primary oxygen-sensing reaction in the kidney which is triggered by a reduction in ambient partial pressure of oxygen (high altitude, hypobaria); a decreased passage of oxygen across the pulmonary endothelium (obstructive lung disease); a decrease in the oxygen-carrying capacity of hemoglobin (anemia); a decrease in oxygen utilization by the kidney (cobalt) (Fisher and Birdwell 1961); and a decrease in the flow of blood to the kidney (renal artery constriction, atherosclerosis, thrombosis).

Supported by USPHS grant DK13211 and Private funds

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Authors
  1. J. W. Fisher
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  2. J. Nakashima
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Editors and Affiliations

  1. Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, 70112, New Orleans, LA, USA

    James W. Fisher Ph.D. (Regents Professor and Chairman) (Regents Professor and Chairman)

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© 1992 Springer-Verlag Berlin Heidelberg

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Fisher, J.W., Nakashima, J. (1992). Kidney Regulation of Erythropoietin Production. In: Fisher, J.W. (eds) Biochemical Pharmacology of Blood and Bloodforming Organs. Handbook of Experimental Pharmacology, vol 101. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75865-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-75865-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75867-6

  • Online ISBN: 978-3-642-75865-2

  • eBook Packages: Springer Book Archive

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