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Targeted Drug Delivery pp 285–327Cite as

In Vivo Behavior of Liposomes: Interactions with the Mononuclear Phagocyte System and Implications for Drug Targeting

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 100))

Abstract

Several years before Bangham et al. (1965a,b) formulated the concept of the liposome as a closed compartment separated from its aqueous environment by one or more lipid bilayers, and even longer before GREGORIADIS and Ryman (1972a) first suggested the use of such liposomes as a potential drug carrier system, intravenous administration of aqueous dispersions of phospholipids was proposed as an anti-atherogenic treatment, facilitating the elimination of cholesterol from the body (Friedman et al. 1957). Even before that, a patent was obtained for the creation of a local depot of steroids, created by applying phospholipid/steroid mixtures, which clearly must have had the structural features of what we now call liposomes (Johnson 1934, cited according to Pagano and Weinstein 1978). However, the enormous boost in liposome literature that we have seen in more recent years did not start before the early 1970s, when Gregoriadis and Ryman (1972b) proposed the enzyme-loaded liposome as an approach to the treatment of (lysosomal) storage diseases. Ever since then, we have seen an exponential growth of literature on the potentials of the liposome as a drug carrier system, culminating over the past 3 or 4 years in a large number of reports on clinical trials concerning a limited number of applications. Much of the work published on liposomes deals with their in vivo behavior, both from a fundamental point of view and with respect to direct applications. Although a considerable share of this latter work serves to moderate the over-enthusiastic conclusions frequently drawn from in vitro experiments with liposomes and cells, it cannot be denied that sometimes spectacular results are reported, mostly on the therapeutic utility of liposomes in animal models of disease.

The work from this laboratory referred to was financially supported by grants from the Netherlands Organization for Scientific Research, the Dutch Cancer Foundation and Ciba Geigy AG, Basel.

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Authors
  1. G. L. Scherphof
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Editors and Affiliations

  1. Department of Pharmacology, University of North Carolina School of Medicine, CB#7365, Faculty Laboratory Office Building, 27599-7365, Chapel Hill, NC, USA

    Rudolph L. Juliano Prof., Ph.D. (Professor and Chairman) (Professor and Chairman)

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© 1991 Springer-Verlag Berlin Heidelberg

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Scherphof, G.L. (1991). In Vivo Behavior of Liposomes: Interactions with the Mononuclear Phagocyte System and Implications for Drug Targeting. In: Juliano, R.L. (eds) Targeted Drug Delivery. Handbook of Experimental Pharmacology, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75862-1_8

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  • DOI: https://doi.org/10.1007/978-3-642-75862-1_8

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