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Targeted Drug Delivery pp 231–284Cite as

Chemical Delivery Systems

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 100))

Abstract

One of the most sought after yet elusive goals of the medicinal chemist is the development of site-or organ-targeted drug delivery systems. The realization of Ehrlich’s “magic bullet” would be a boon to therapeutic intervention in many disease states. The reason for this, of course, is selectivity. If a systemically or orally administered agent concentrates in its pathophysiologically relevant site, not only would the efficiency of the drug be enhanced but also the toxicity of the material may well be mitigated. This latter point is a consequence of attenuating non-target site drug levels. Lowering the toxicity of a drug is of equal importance to enhancing potency in terms of optimizing the therapeutic index, i.e., the ratio of the median effective and toxic doses.

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  1. N. Bodor
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Editors and Affiliations

  1. Department of Pharmacology, University of North Carolina School of Medicine, CB#7365, Faculty Laboratory Office Building, 27599-7365, Chapel Hill, NC, USA

    Rudolph L. Juliano Prof., Ph.D. (Professor and Chairman) (Professor and Chairman)

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Bodor, N., Brewster, M.E. (1991). Chemical Delivery Systems. In: Juliano, R.L. (eds) Targeted Drug Delivery. Handbook of Experimental Pharmacology, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75862-1_7

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  • DOI: https://doi.org/10.1007/978-3-642-75862-1_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75864-5

  • Online ISBN: 978-3-642-75862-1

  • eBook Packages: Springer Book Archive

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