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Therapeutic use of Omeprazole in Man: Pharmacology, Efficacy, Toxicity, and Comparison with H2 Receptor Antagonists

  • Chapter
Pharmacology of Peptic Ulcer Disease

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 99))

Abstract

The inhibition of gastric secretion by altering the activity of the terminal step of acid secretion is a new approach to the therapy of peptic ulcer disease. The active transport of HCl is carried out by a transport enzyme, the H+,K+-ATPase. The steps necessary for the formation of acid involve activation of the ATPase in several steps that include (a) insertion of the protein into the canalicular membrane of the parietal cell and (b) activation of KCl permeability of the canalicular membrane so that K+ can access the luminal surface of the enzyme and enable ATPase activity and hence acid secretion (Fig. 1). The mechanism of acid secretion has been discussed in detail elsewhere in this volume. The clinical use of one inhibitor of the H+,K+-APTase, omeprazole, is gaining increasing acceptance worldwide and this review is concerned with published studies of the properities of omeprazole in man.

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Authors
  1. P. N. Maton
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  2. G. Sachs
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  3. B. Wallmark
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA

    Martin J. Collen M.D., F.A.C.P. (Professor of Medicine, Chairman of Research) (Professor of Medicine, Chairman of Research)

  2. Division of Gastroenterology, Georgetown University Hospital, Washington DC, 20007, USA

    Stanley B. Benjamin M.D., F.A.C.P. (Professor of Medicine and Chief) (Professor of Medicine and Chief)

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© 1991 Springer-Verlag Berlin Heidelberg

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Maton, P.N., Sachs, G., Wallmark, B. (1991). Therapeutic use of Omeprazole in Man: Pharmacology, Efficacy, Toxicity, and Comparison with H2 Receptor Antagonists. In: Collen, M.J., Benjamin, S.B. (eds) Pharmacology of Peptic Ulcer Disease. Handbook of Experimental Pharmacology, vol 99. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75858-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-75858-4_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75860-7

  • Online ISBN: 978-3-642-75858-4

  • eBook Packages: Springer Book Archive

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