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Pharmacology of Prophylactic Anti-Asthma Drugs

  • Chapter
Book cover Pharmacology of Asthma

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 98))

Abstract

Among the different classes of drugs used in the treatment of asthma, the bronchodilators (β2-adrenoceptor agonists, muscarinic receptor antagonists, methylxanthines) bring symptomatic relief but contribute little to ameliorating the underlying bronchial inflammation. Glucocorticoids (see Chap. 8) exert a potent antiinflammatory effect and, particularly when inhaled, have both therapeutic and prophylactic value. The drug that is now accepted clinically as having a prophylactic effect in asthma, whilst only rarely bringing symptomatic relief, is cromoglycate; the recently introduced nedocromil is another example of the same class of compound. Ketotifen has a different pharmacological profile and has gained some acceptance as a prophylactic agent in asthma. This chapter will only review the pharmacology of drugs in clinical use (cromoglycate, nedocromil, ketotifen), although there is much current research directed towards finding other new types of antiinflammatory agents to be used as first-line durgs in mild asthma, leaving glucocorticoids for treatment of severe asthma.

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Authors
  1. L. G. Garland
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Editors and Affiliations

  1. Department of Pharmacology, King’s College University of London, Manresa Road, SW3 6LX, London, Great Britain

    Clive P. Page B.Sc.,Ph.D. (Reader in Pharmacology) (Reader in Pharmacology)

  2. Department of Thoracic Medicine, National Heart and Lung Institute, Dovehouse Street, SW3 6LY, London, Great Britain

    Peter J. Barnes M.A.,D.M.,D.Sc.,FRCP (Professor of Thoracic Medicine) (Professor of Thoracic Medicine)

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Garland, L.G. (1991). Pharmacology of Prophylactic Anti-Asthma Drugs. In: Page, C.P., Barnes, P.J. (eds) Pharmacology of Asthma. Handbook of Experimental Pharmacology, vol 98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75855-3_9

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