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Pharmacology and Therapeutics of β-Adrenoceptor Agonists

  • R. G. Goldie
  • J. W. Paterson
  • K. M. Lulich
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 98)

Abstract

Asthma is a disease involving reversible airway obstruction (Paterson et al. 1979; Norn and Skov 1980) with an associated non-specific bronchial hyperreactivity to bronchoconstrictor stimuli (Boushey et al. 1980; Paterson et al. 1984; Woolcock 1986). Airway obstruction in asthma is produced by a combination of bronchospasm and inflammation (Woolcock 1986; Barnes 1987). The inflammatory component is characterized by mucosal and bronchial wall oedema, lymphocyte and eosinophil infiltration, desquamation of the airway epithelium and the presence of mucus plugs within the airway lumen (Reed 1986). In recent years, there has been a greater appreciation of the inflammatory nature of the disease and, as a result, the therapeutic emphasis in asthma has moved away from bronchodilator drugs, i.e. those drugs inducing relaxation of constricted airway smooth muscle (Reed 1986; Woolcock 1986).

Keywords

Airway Smooth Muscle Allergy Clin Immunol Myosin Light Chain Kinase Bronchial Smooth Muscle Adrenoceptor Agonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • R. G. Goldie
  • J. W. Paterson
  • K. M. Lulich

There are no affiliations available

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