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Pharmacology of Airway Smooth Muscle

  • I. W. Rodger
  • R. C. Small
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 98)

Abstract

In undertaking to write on the subject of the pharmacology of airway smooth muscle we have deliberately chosen not to produce an exhaustive review of the literature on the subject. Given the space constraints, it would be inappropriate to try to do so. Instead we have chosen to focus upon the excitation-contraction (E/C) coupling and uncoupling mechanisms that exist in airway smooth muscle. Thus, this chapter presents both biochemical and pharmacological information on contraction and relaxation mechanisms. In the context of drug-induced relaxation of airway smooth muscle we have been selective in concentrating on the actions of those drugs (β-adrenoceptor agonists and alkylxanthines) that are currently the principal bronchodilators in the therapy of asthma. In presenting much of the information contained in this chapter we have attempted to cite key references. Where appropriate, reference to relevant review articles has also been made.

Keywords

Airway Smooth Muscle Intracellular Store Airway Smooth Muscle Cell Muscarinic Agonist Tracheal Smooth Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • I. W. Rodger
  • R. C. Small

There are no affiliations available

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