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Pharmacology of Airway Smooth Muscle

  • Chapter
Pharmacology of Asthma

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 98))

Abstract

In undertaking to write on the subject of the pharmacology of airway smooth muscle we have deliberately chosen not to produce an exhaustive review of the literature on the subject. Given the space constraints, it would be inappropriate to try to do so. Instead we have chosen to focus upon the excitation-contraction (E/C) coupling and uncoupling mechanisms that exist in airway smooth muscle. Thus, this chapter presents both biochemical and pharmacological information on contraction and relaxation mechanisms. In the context of drug-induced relaxation of airway smooth muscle we have been selective in concentrating on the actions of those drugs (β-adrenoceptor agonists and alkylxanthines) that are currently the principal bronchodilators in the therapy of asthma. In presenting much of the information contained in this chapter we have attempted to cite key references. Where appropriate, reference to relevant review articles has also been made.

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Authors
  1. I. W. Rodger
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  2. R. C. Small
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, King’s College University of London, Manresa Road, SW3 6LX, London, Great Britain

    Clive P. Page B.Sc.,Ph.D. (Reader in Pharmacology) (Reader in Pharmacology)

  2. Department of Thoracic Medicine, National Heart and Lung Institute, Dovehouse Street, SW3 6LY, London, Great Britain

    Peter J. Barnes M.A.,D.M.,D.Sc.,FRCP (Professor of Thoracic Medicine) (Professor of Thoracic Medicine)

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© 1991 Springer-Verlag Berlin Heidelberg

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Rodger, I.W., Small, R.C. (1991). Pharmacology of Airway Smooth Muscle. In: Page, C.P., Barnes, P.J. (eds) Pharmacology of Asthma. Handbook of Experimental Pharmacology, vol 98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75855-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-75855-3_4

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  • Print ISBN: 978-3-642-75857-7

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